基于D-A型七甲川菁构筑电荷转移超分子聚合物光学诊疗体系

以有机小分子光敏剂作为基元，构筑功能超分子聚合物材料，不仅能够更好地理解“单体结构-聚合物拓扑结构-功能”的关系，还能推动光学诊疗技术的发展和临床应用。本项目拟以七甲川菁类光敏剂作为单体，构筑电子转移超分子聚合物。探索七甲川菁供受电子能力、分子π电子共平面程度及空间位阻等对电荷转移复合物结合常数的影响；将多重相互作用引入到分子结构的设计中，优化弱相互作用的加合性、协同性和方向性，调控并稳定超分子聚合物的拓扑和组装结构。结合共聚或聚合-后修饰等手段，实现诊疗功能的集成与协同，不断优化结构，探索基于小分子光敏剂的超分子聚合物在肿瘤诊疗领域的应用。

Supramolecular theranostic polymer (STP) assembled from the small organic molecule photosensitizers (PS) are highly adaptable platforms to combine treatment and diagnosis for the personalized therapy. Not only the development of STPs can facilitate to better understand the relationship between the molecular structures of PS and the self-assembly morphology that contributes to their theranostic effects, but also promote the clinical translation of optical theranostic technology. In this proposal, we aim to explore the ability of accepting/donating electrons, coplanarity, and steric hindrance of heptamethine cyanines (Cy7) structure to construct supramolecular charge transfer polymer with precise nanostructures. The multifunctional STP will be prepared via co-polymerization of functionalized monomer or post-polymerization modification. By optimizing the cooperation, synergy, and directionality of multiple non-covalent interactions in the design of Cy7, the relationship of theranostic properties with molecular structure and assemble morphology will be systematically investigated.The obtained information will guide us the new design and synthesis of PS monomer to optimize the optical theranostic properties of supramolecular polymer. Finally, these PS-based STP will be further investigated as supramolecular nanomedicines that are self-delivering and self-formulating for tumor diagnosis and therapy.