B细胞通过免疫复合物破坏血脑屏障促进乳腺癌脑转移的机制研究

乳腺癌是最易发生脑转移（Brain Metastases，BM）的实体肿瘤之一，血脑屏障（Blood-Brain Barrier，BBB）的破坏与BM的发生密切相关。但在肿瘤微环境（Tumor environment，TME）中，B细胞所介导的体液免疫对肿瘤转移的作用尚未阐明。预实验结果证明脑转移的发生与B淋巴细胞破坏BBB的完整性密不可分，本课题拟在前期预实验的基础上进一步探究B细胞是否可以通过分泌病理性抗体，与血管内皮细胞上的Fc受体结合形成免疫复合物（Immune complex，IC），破坏BBB，促进BM发生。同时，拟在临床资料中进一步验证，有助于理解B细胞介导的体液免疫在肿瘤转移，尤其是脑转移当中的作用，为靶向肿瘤微环境治疗乳腺癌提供新的分子靶点。

Breast cancer is one of the solid tumors most likely to develop Brain metastases(BM).BM often impaired the integrity of blood-brain barrier（BBB）. the role of B cells and their derived humoral immunity in tumor microenvironment（TME） are poorly defined, especially in the brain metastasis microenvironment. In our previous study, we showed that B lymphocytes could breakdown the BBB, which was closely related to BM. We intend to futher explore whether B cells could promote BM through secrete pathological antibodies, which bound to Fc receptors on vascular endothelial cells. Meanwhile, we'll vetify this in the clinical data. Above all, Our study will be helpful for further understand the role of B cell-mediated humoral immunity in tumor microenvironment, and provide new molecular targets for therapies against breast cancer BM.