光热和光动力疗法为肿瘤提供了新途径，具有重要的科学意义和应用价值。光动力疗法存在对深层肿瘤的治疗效果较差、对组织氧浓度有依赖等方面的不足；且由于存在热休克反应，光热作用需要较大的光强度才能有效杀死癌细胞。因此，两种方法联合使用有望提升治疗效果，但目前多数研究中使用两束激发光分别诱导光动力作用和光热作用，在深层肿瘤中难以实现两种作用的有效协同。本项目拟构建一种高效的光热光动力探针，实现在近红外光激发下的光热和光动力协同治疗。计划将表面多尖端结构的金纳米狼牙棒和光敏剂ICG的结合体、以及17AAG共同包裹于热敏脂质体中，表面多尖端结构的存在可提高金纳米棒的光热转换效率，同时增强其表面光敏剂ICG的光动力效率，而17AAG可通过抑制热休克反应提升光热作用效率。几种作用集成一体，最终实现对肿瘤的高效光疗效果。

Photothermal therapy and photodynamic therapy provide a new approach for the treatment of tumors, but photodynamic therapy has a poor therapeutic effect on deep tumors and its efficiency relies on the concentration of tissue oxygen. On the other hand, due to the existence of heat shock response, a high light intensity is required in photothemal effect to kill cancer cells. The combination of the two for the treatment of tumors can improve the therapeutic effect on tumors. However, in most of the current research, two excitation laser are used to excite photodynamic effect and photothermal effect respectively, which is difficult to achieve the combined effect in deep tumors. This project intends to construct an efficient synergy system to achieve photothermal and photodynamic effect simultaneously under the excitation of near infrared laser, and improve the therapeutic effect of phototherapy on tumors. When the system was constructed, a combination of a multi-tip structure gold nanorod and photosensitizer ICG was co-wrapped with 17AAG in a thermosensitive liposome. The presence of multi-tip structure on the surface of gold nanorods can improve the photothermal conversion efficiency of gold nanorods and enhance the photodynamic efficiency of the photosensitizer ICG on its surface. 17AAG can also inhibit the heat shock reaction of tumor cells and enhance the efficiency of photothermal effect. Finally, the synergy between photothermal therapy and photodynamic therapy is achieved.