基于脊髓-脑多模态MRI和周围神经电生理学的纵向研究探讨DPN机制

糖尿病周围神经病变（Diabetic Peripheral Neuropathy，DPN）是糖尿病最常见的并发症之一，严重影响患者的预后及生活质量。以往多项研究和我们的前期研究均已证实DPN患者存在中枢神经系统功能和结构的改变，但中枢神经系统改变与周围神经病变之间的因果或者交互关系并未完全清楚。本项目拟采用前瞻性队列设计，从疾病暴露时开始研究，联合运用脊髓-脑多模态MRI技术（包括结构和功能MRI），同步纵向分析脊髓-脑表征和周围神经电生理的变化，以期发现DPN患者脑、脊髓结构和功能MRI特点与周围神经电生理改变在疾病起病前和疾病发生发展过程中的动态变化规律及相互关联，进一步阐明DPN的中枢机制及作用路径，并构建以中枢神经系统特征为导向的预测模型，为疾病的早期诊治和防控提供理论依据。

DPN, one of the most common complications of diabetes, severely affects the prognosis and quality of life in diabetic patients. Several pre-studies and our previous investigations verified the structural and functional abnormities of the central nervous system, but the causality/interaction with peripheral never lesions in DPN patients remained unknown. In this prospective cohort study, our team intends to study from disease exposure, combine spinal cord-brain multi-modal MRI technique (including structural and functional MRI), analyze the alteration of spinal cord-brain image characteristics and peripheral neural electrophysiology data simultaneously and longitudinally. We expect to discover the relevance and the regularity between the central MRI specialties and peripheral neural electrophysiology from the DPN onset to its evolution, clarify DPN central mechanism and its acting path, build the prediction model in the direction of central features and provide a theoretical basis for the early diagnosis and prevention together with treatment of DPN.