基于超声-电磁多模态成像引导与反馈的磁致热疗研究

磁致热疗是利用磁性颗粒在外加磁场作用下产热，从而对肿瘤组织进行局部加热的一种有效治疗手段。将磁致热疗和医学成像结合起来，为治疗过程提供图像引导和反馈是目前发展的趋势。本项目在前期工作的基础上，以磁纳米粒子为介导，将磁致振动成像、弹性成像和磁致热疗结合起来，创新地提出一种基于超声-电磁多模态成像引导与反馈的磁致热疗新方法。该方法能获取磁纳米粒子的浓度分布，以及局部区域的弹性系数，从而为治疗方案的制定和疗效评估提供重要信息。本项目将在研究平台集成与开发、诊疗一体新方法研究、诊疗一体新方法的肿瘤热疗应用等方面深入研究，解决磁纳米探针制备与表征、多模态成像算法、诊疗一体引导与反馈机制等关键问题，并通过小动物实验对新方法的肿瘤热疗应用进行探索。本项目有望在肿瘤的磁致热疗技术上有突破性的进展，为临床肿瘤治疗提供一种处于国际领先水平的新方法。

Magnetically induced hyperthermia is an effective treatment that uses magnetic particles to generate heat under the action of an external magnetic field, thereby locally heating tumor tissue. It is the current development trend to combine magnetic thermotherapy and medical imaging to provide image guidance and feedback for the treatment process. Based on the previous work, this project uses magnetic nanoparticles as a medium to combine magnetomotive imaging, elastography and magnetically induced hyperthermia, and innovatively proposes an acousto-electromagnetic multimodal imaging method for magnetically induced hyperthermia with guidance and feedback. This method can obtain the concentration distribution of magnetic nanoparticles and the local elastic coefficient of the magnetic nanoparticle region, so as to provide important information for the formulation of the treatment plan and the evaluation of the efficacy. This project will conduct in-depth research in the development of research platforms, new methods of diagnosis and treatment integration, and application of new methods. The key problems will be solved, such as the preparation and characterization of magnetic nanoprobes, multi-modal imaging algorithms, and guidance and feedback mechanisms. The preliminary clinical application of the new method will be explored through small animal experiments. This project is expected to make a breakthrough in the magnetic thermotherapy technology of tumors, and provide a new method at the international advanced level for clinical tumor treatment.