肝细胞癌（Hepatocellular carcinoma, HCC）是一种原发于肝脏的恶性肿瘤，在我国肝癌中占85%~90%，其特点是发病率高、预后差，因此早期诊断至关重要。医学成像技术是HCC临床诊断的主要方法，其发展趋势是分子影像、多模态、多功能。本项目在前期工作的基础上，针对HCC早期诊断创新性地提出一种分子影像新方法：超声-电磁多模态分子影像。该方法以超声超快成像为核心，结合分子探针和电磁激励，可以获取多种反映HCC特征的结构和功能图像，包括：超声灰阶图像、血管微结构图像、纳米探针分布图像、弹性图像，为HCC诊断提供多模态信息。本项目拟从分子探针制备与表征、理论与算法研究、成像方法测试与应用三个方面对新方法进行研究，通过动物模型实验探索该方法在HCC早期检测中的应用。本项目研究有望建立一种对HCC可治愈阶段进行早期检测的分子影像新方法，为早期HCC的预防性干预提供新手段。

Hepatocellular carcinoma (HCC) is a primary carcinoma of liver, which accounts for 85-90% amount of liver cancer in China. Because of its properties of high prevalence rate and poor prognosis, the early detection of HCC is very important. Medical imaging is the primary method for clinical diagnosis of HCC, which has the trend of molecular imaging, multimodality, and multifunction. Based on the previous work, this project proposes an innovative molecular imaging method for the early detection of HCC: Acoustic-electromagnetic multimodal molecular imaging. This method uses ultrafast ultrasound imaging as kernel, and combines molecular probe an electromagnetic stimulation to obtain structural and functional images for HCC characteristics. This project will explore the new method from three aspects: preparation and characterization of molecular probes, theory and algorithm research, and imaging method test and application. The feasibility of HCC detection with this method is explored by animal model experiment. The research of this project may establish a new method for early detection of HCC in the curable stage, and provide a new technique for early preventive intervention of HCC.