无机磷酸转化为有机膦的合成应用研究

发展无机磷酸向有机膦转化的绿色方法和技术是磷化学面临的最具挑战性的问题之一。本项目针对P-B键的独特性质和磷酸难于还原的问题，通过提高磷酸的Lewis酸性和活化P=O双键等手段，将磷酸转化为结构新颖、多样化的硼基/硅基磷负离子，并以此磷负离子为合成子，发展含磷有机物和含磷合成子的合成新方法。研究内容包括以下三方面: 一是硼基磷负离子的制备；二是硼基磷负离子的亲核反应；三是硼基磷负离子的交叉偶联反应。通过上述研究为无机磷向有机膦转化这一科学问题探索新的解决方案，同时为代表性有机膦分子和磷合成子的制备发展高效的合成策略。该项目研究对丰富含磷化合物的转化和制备方法具有重要的学术意义，对推动我国磷化工行业的绿色高效发展具有潜在的实用价值。

The development of alternative approach avoiding white phosphorus to produce organophosphorus compounds remains a significant challenge in phosphorus chemistry. Being point at the special characters of P-B bond and the unreactive phosphoric acid, the project will establish a new and efficient method for reducing phosphoric acid to constructe boranophosphide anion by enhancing the Lewis acid and activating the P=O bond of phosphoric acid. This project contains the following three contexts: synthesis of boranophosphide anion; nucleophilic reaction of boranophosphide anion and cross-coupling reaction of this anion. The implementation of this project will offer a new route between the inorganic phosphoric acid and organophosphorus. It will also highlight new synthetic utilization in organophosphorus and phosphorus synthons. The development of green and efficient methodologies for transformation and preparation of phosphorus compounds is needed in academia and industry field.