烯丙基胺类化合物具有重要的生物活性，广泛存在于生物活性天然产物中；烯丙基胺类化合物也是一类重要的合成中间体，可用于内酰胺、吲哚、生物碱、氨基酸、烯丙基伯胺等的合成中。研究烯丙基胺的合成并将其用于生物活性杂环化合物的合成具有重要意义。 本项目选择烯丙基胺的合成及其成环反应为研究对象，以非贵金属催化下仲酰胺或仲胺与多聚甲醛（或乙醛酸乙酯）、未活化烯烃的三组分反应合成烯丙基胺类化合物及多取代喹啉，再经烯丙基胺的成环反应合成含有呋喃、噁唑、噻唑、喹啉、吲哚、嘧啶等结构单元的杂环化合物为主要研究内容。提供通过廉价易得原料的多组分一锅法反应合成结构多样性烯丙基胺类化合物及其衍生物的新合成方法，并应用于具有重要生物活性烯丙基胺的合成中。开发非过渡金属催化下以未活化烯烃和廉价易得的原料合成烯丙基胺类化合物的合成方法为此类化合物的合成及应用研究奠定基础。

Allylamines are of great importance in organic synthesis. They are found in a wide variety of bioactive natural products, and are useful intermediates to a range of products such as indoles, alkaloids, amino acids, etc. This study will focus on the synthesis of allylamines and their utilization in the synthesis of some biologically active compounds. We will study the acids promoted three-component reaction for allylamines that performs the direct aminomethylation starting from styrene, amids or amines and aldehyde as cheaper and easy-available starting materials. We will also design and synthesize biologically active heterocycles containing pyrimidines, furan, oxazolo, thiazolo, quinoline, or indole structure using the allyamines as starting materials. This project intend to develope processes that allow using styrenes, commercially availability and cheaper materials under transition-metal catalyst free conditions for the construction of complex and muti-substitution allylic amines.