基于生物力学适配特征的胫骨结节骨骺炎发生机制与防护方法研究

胫骨结节骨骺炎主要发生于青少年快速生长期，发病率高达9.8%；现有研究主要从胫骨结节周围组织结构形态特征及功能特性、运动强度与运动方式、骨骺生长发育情况等方面讨论其发病机制，但迄今尚未形成共识，这已经成为对胫骨结节骨骺炎进行预测、评估和防护急需解决的瓶颈问题。. 本项目提出，胫骨结节骨骺受力与其自身强度的生物力学适配特征，可能是决定胫骨结节骨骺炎是否发生的根本原因。为此，本项目将建立基于多刚体动力学和有限元耦合建模的胫骨结节骨骺受力分析方法，研究基于影像特征评估胫骨结节骨骺表观强度的方法，并通过患者和健康人的对比，分析生物力学适配性与胫骨结节骨骺炎之间的关系，在此基础上，提出基于生物力学适配性的胫骨结节骨骺风险预测与防护方法。本项目的研究成果对于进一步理解胫骨结节骨骺炎的发病机制，有效提升防护效果具有重要的意义。

Osgood–Schlatter Disease (OSD) mainly occurs in the rapid growth period of adolescents, and the incidence rate is as high as 9.8%. Many researchers have investigated the effects of structural / functional characteristics of tissues around tibial tubercle, athletic overuse, and growth states of epiphysis. However, the mechanism is still not clear, which has become a problem for the prediction, evaluation and protection of OSD. . We suppose that it is the matching state of biomechanical behavior that determines whether OSD occurs or not. This project will integrate multibody dynamics and finite element modeling to analyze the stress distribution in the tibial tubercle epiphysis, and develop a method of evaluating the apparent strength of the epiphysis according to image features. Then, the relationship between the matching state of biomechanical behavior and the occurrence of OSD will be constructed by comparing OSD and health subjects. After that, the method for predicting and protecting OSD according to matching state of biomechanical behavior will be proposed. The results of this project will be useful for further understanding the mechanism of OSD and developing effective protective treatment of OSD.