足溃疡及其导致的截肢是糖尿病最严重的并发症之一；足底压力增大等生物力学因素对引发糖尿病足溃疡具有重要影响。然而，临床应用中发现，仅以足底压力作为指标来评估糖尿病足溃疡风险和制定干预措施并不总是有效。因此，全面分析足底组织特性变化规律及其对力学刺激的响应，有助于从生物力学角度深入理解糖尿病足溃疡的机制。. 本项目将以糖尿病患者对象，采用实验和仿真计算相结合的方法，从足底负荷-血流-温度关系及其对溃疡的作用、复合载荷累积作用下足底胼胝的形成规律、足底深部组织应力分布对溃疡的影响三个方面开展纵向研究，进一步阐明生物力学因素在糖尿病足溃疡形成过程中的作用机制，并建立基于足底组织生物力学响应的糖尿病足溃疡风险评估方法。本项目的研究成果对于更准确地评估溃疡风险和制定有效干预措施，从而有效提高糖尿病患者生活质量有重要意义。

Foot ulcers and eventual limb amputation are one of the most serious complications of diabetes mellitus. Biomechanical factors such as elevated plantar pressure play important effect on the occurrence of diabetic foot ulcers. However, the clinical effect of only choosing plantar pressure as indicator for assessing ulcer risk and formulating therapeutic plan is not good. Thus, it’s very necessary to comprehensively consider the change regularity of plantar tissue property and its biomechanical response, which contributes to further understand the mechanism of diabetic foot ulcers from the perspective of biomechanics. .This project will carry out three longitudinal studies: the relationship of plantar load-blood perfusion-temperature, and its effect on ulcers; formation regularity of plantar callus under accumulation of composite load; and the effect of plantar deep tissue stress distribution on ulcers formation. Based on these researches, this project will further clarify the impact of biomechanical factors on the formation mechanism of diabetic foot ulceration, and provide method for evaluating the risk of foot ulcers. The results of this project will be useful for quantitative assessment of ulcer risk, make effective intervention treatment and improve life quality of patients with diabetic foot.