圆柱瘤蛋白（CYLD）对心肌功能的调控及机制研究

CYLD首先作为肿瘤抑制因子被认识，研究发现CYLD在多种重要的生物学活动中可发挥重要作用。前期有研究显示CYLD还同心脏功能有关，但其中的作用机制尚不明确。本课题计划围绕CYLD对心脏功能的影响和内在的调控机制展开基础理论和临床相关的研究工作，具体包括：首先在动物模型水平上明确CYLD蛋白对心脏功能有调控作用；其次利用细胞为材料，研究CYLD是如何影响细胞连接等细胞活性并关联到心脏功能的；同时在分子水平探究CYLD行使功能的相关机制，分别剖析CYLD的去泛素化酶活性和蛋白结合功能在其中如何发挥作用；最后还要评价CYLD对临床应用的价值。项目研究结果将有助于揭示CYLD参与心脏功能调节的内在机制，并为后续的临床应用研究打好基础。

CYLD was identified as a tumor suppressor from patients with familial cylindromatosis. CYLD was proved to participate in the suppression of CYLD was discovered as a tumor suppressor. Subsequent studies have shown that CYLD plays a role in many important biological activities. Early stage It has been found that CYLD is also related to cardiac function, but the mechanism is not clear. This project focuses on the cardiac function of CYLD. Influences and intrinsic regulatory mechanisms to carry out basic theoretical and clinical related research work, including: first of all, to clarify the CYLD protein on cardiac function. Secondly, we study how CYLD affects cell activity such as cell junction and is related to cardiac function. At the same time, we also explore CYLD. Molecular mechanism of its function, analysis of its deubiquitinase activity and protein binding function in which how to play a role, but also to evaluate CYLD on the role of The value of clinical application. The results of this study will help to reveal the intrinsic mechanism of CYLD involvement in cardiac function regulation and provide further research for clinical application. Research lays a good foundation.