由于蛋白质吸附而引起材料表面生物污损不仅导致材料功能下降，在医疗器械中发生则可能威胁病人的生命，构建防生物污损的聚合物刷涂层技术在许多领域有重要应用。本项目拟设计制备具有多巴胺端基的两性离子聚合物，集“万能胶”和“抗粘附”两种对立性质于一身，利用溶液吸附方式可以简单有效地构建具有良好的生物相容性和优异抗蛋白吸附性能的聚合物刷。项目拟对两性离子聚合物刷的制备方法、两性离子聚合物与不同性质基材的相互作用、两性离子聚合物刷的表面形态、表面物理化学性质及其抗生物污染性能等进行系统研究，深入理解高分子与材料的界面相互作用、材料表面与生物大分子之间的相互作用规律，为开发普遍适用的抗吸附聚合物刷提供新的思路，为大面积、简单有效地表面改性提供新的途径，为仿生的两性离子化表面设计提供新的策略。

The surface biofouling induced by protein adhesion will decrease material proformance and may threaten human health. The development of anti-fouling surfaces from the polymer brush modification treatment based on the “grafting-to” method would be of great practical significance to national defence and economy. In this project, zwitterionic polymers with surface-adhesive end groups will be designed and synthesized by combining "universal glue" and "anti-adhesion" two contradictory properties. By using a solution adsorption method, i.e., “grafting-to” method, the zwitterionic polymers will be attached on various surfaces to fabricate the zwitterionic polymer brushes with anti-fouling properties. The complex interactions between polymer and substrate and interactions between substrate and biomacromolecules which will provide modified surfaces with different surface energies, surface chemistries, surface topographies and protein adhesion abilities will be systematically studied. The polymer and polymer brush designs will satisfy the desire of the convenient and simple to be implemented on surfaces with large and intricate shapes. The versatile method and the bioinspired design will provide chances and strategies to non-fouling surface modification.