特定结构氟卟啉高分子的构建、组装及其在光动力治疗中的应用

当前，高分子自组装仍是高分子学科重要研究领域之一，尤其功能性自组装体的构建和应用为高分子自组装研究重点。在本申请中，申请人拟基于课题组新开发的近红外氟卟啉分子，将其功能化为聚合反应所用的单体、引发剂或链转移剂等，制备一系列两亲性特定结构氟卟啉高分子；系统地探究此类特定结构氟卟啉高分子的自组装行为，希望获得不同于传统两亲性高分子的自组装结构和组装机理等；最后，申请人重点研究氟卟啉高分子自组装体在光动力治疗中的应用。针对卟啉小分子光敏剂在光动力治疗过程中效率低下等问题，申请人将通过近红外氟卟啉高分子的结构设计、自组装体形成，重点解决卟啉类光敏剂吸收光的波长短而造成的组织穿透性差、肿瘤乏氧等问题，从而提升卟啉类光敏剂在光动力抗癌治疗中的治疗效果，同时亦拓展了高分子自组装体的应用领域。

The polymer self-assembly is still one of important research fields in polymer science, especially for construction and application of functional polymer assemblies. In this proposal, the applicant will prepare a series of well-defined fluoroporphyrin-based amphiphilic copolymers by modification of fluoroporphyrin derivatives as monomers, initiators and chain transfer agents. The self-assembly behavior of amphiphilic fluoroporphyrin copolymers will be systematically investigated, and then some interesting assembled nanostructures and mechanisms will be achieved, which will be different with those formed from conventional amphiphilic copolymers. Finally, the applicant will focus on the application of fluoroporphyrin polymeric assemblies in photodynamic therapy (PDT). To address the low efficacy of small molecular photosensitizers in PDT, the applicant will work on overcoming the poor tissue penetration of photosensitizer-absorbed light and tumor hypoxia, and then enhancing efficiency of photosensitizers in PDT via the design of the amphiphilic copolymers and varying self-assembly conditions, which will also extend the applications of polymer assemblies.