当前，基于主客体相互作用所形成的超分子化学引起了研究者的广泛关注，因为通过主客体之间的包结络合作用形成的超分子包结物或组装体在生物医药、化学传感以及催化等前沿领域显示出潜在的应用前景。在此申请中，申请人将功能性卟啉分子和主客体基元相结合，通过主客体之间相互作用构建一系列含卟啉特定结构的超分子聚合物，并对其结构、组装形态和性能进行系统地研究。最后，申请人将重点研究含卟啉超分子聚合物在光动力学治疗中的应用。申请人拟通过分子设计将卟啉分子和具有一定分子尺寸的主客体基元直接结合，有效地减少卟啉基元之间的π-π相互堆积，提高卟啉基元的光物理性能，解决卟啉类光敏剂单线态氧产率低等问题。同时通过超分子聚合物的结构设计以及自组装体的形成，解决卟啉类光敏剂水溶性差，非特异选择性等缺点，提高卟啉光敏剂在光动力治疗中的药物利用率，最终获得适合光动力治疗的含卟啉的超分子光敏剂。

Nowadays, the supramocular chemistry based on host-guest interaction has attracted great attention, since supramolecular complexes or assemblies formed by the inclusion complexation of host-guest interaction exhibit greatly potential applications in some advanced fields such as biological medicines, chemsensors and catalysis. In this proposal, we will fabricate a series of porphyrin-based well-defined supramolecular polymers by the conjugation of porphyrin and host/guest moieties, and further sysmetically study their structures, assemlied morphologies and properties. We will explore the application of porphyrin-based supramolecular polymer in photodynamic therapy. The porphyrin molecules will be directly conjugated with host/guest moieties, which could effectively overcome the π-π stacking between porphyrin units, improve the photophysical properties and resolve the issue on lower singlet oxygen yield of porphyrin photosensitizers. Meanswhile, the low water solubility and non-selectivity will be overcome to enhace the efficiency of porphyrin photosensitizers in photodynamic therapy by construction of novel supramolecular architecture and formation of porphyrincic assemblies, and finally the supramolecular porphyrin photosensitizers with high performances will be achieved for photodynamic therapy.