口腔微生物组-宿主共代谢调控黏膜免疫微环境机制研究

口腔微生物不仅影响口腔的局部健康，而且与全身系统性疾病密切相关。本研究基于前期建立的首个中国人群口腔微生物样本库，从微生物组宏基因组和代谢组及宿主代谢组入手，挖掘口腔微生物多样性，种群之间的相互作用以及其与环境之间的关系，探讨关键微生物对口腔健康状态的调控作用以及口腔微生物-宿主共代谢维持口腔黏膜免疫稳态的机制。深度挖掘口腔微生物组学等多维度数据价值，以期开发新的数据模型，为诊前精准评估、诊中精确施治及预后精准判断提供坚实理论基础和适宜工具。

Oral microorganisms not only affect the local health of the mouth, but also closely related to systemic diseases. Relying on the first Chinese oral microbial sample bank established, the research explored the oral microbial diversity, the interaction between populations and its relationship with the environment, starting from the microbial macrogenomes, metabolic groups and host metabolic groups. We aim to explore the regulation of key microorganisms on oral health and the mechanism of oral microbial-host co-metabolism to maintain oral mucosal immune homeostasis. We will also develop new models based on deeply excavating the value of multi-dimensional data, including oral microbiome data, to provide a solid theoretical foundation and appropriate tools for accurate evaluation before diagnosis, precision treatment during diagnosis, and accurate prognosis judgment.