转移是恶性肿瘤的致死的主要原因，并严重影响患者的生存质量和预后。因此寻找促肿瘤转移的关键分子对肿瘤的早期诊断和治疗具有重要的意义。前期我们已发表文章证明高表达癌基因Suprabasin可促进肿瘤恶性增殖。近期通过分析临床乳腺癌样品，我们发现Suprabasin表达与乳腺癌N、M分期显著相关，提示Suprabasin可能促进肿瘤转移。体内、外生物学功能试验结果显示：上调Suprabasin可①诱导乳腺癌细胞发生EMT；②驱动乳腺癌淋巴结、远处器官转移并促血管增生；③增强乳腺癌细胞“干细胞”特性。结合免疫共沉淀耦联质谱等多种方法进行调控机制探讨，结果发现：Suprabasin与Wnt/β-catenin、NF-κB 和AKT信号通路相关调控因子结合并激活其活性。本研究将深层次解析癌基因Suprabasin多层面驱动乳腺癌转移的分子机制，并与临床相结合，为乳腺癌转移提供新的诊断标记物及治疗靶标。

Tumor metastasis is the main cause of malignant death. It is of great importance to find diagnostic factor for tumor metastasis. Our previous published article reported Suprabasin promotes tumor proliferation. However, the function and mechanism of Suprabasin in breast cancer remains unknown. Recently, we found that the expression of Suprabasin was significantly correlated the N and M classification in breast cancer, indicating the potential function of Suprabasin on breast cancer metastasis. The results of in vitro and in vivo experiments in breast cancer showed that upregulation of Suprabasin induced epithelial-mesenchymal transition, promoted lyphmtic, distant metastasis and angiogenesis, enhanced breast cancer stem cell characterics. The results also showed Wnt/β-catenin, NF-κB and Akt signaling pathway might play roles in Suprabasin function and regulation. In current study, we will combine both in vitro and in vivo experimental systems with data from clinical samples, in order to investigate the mechanisms of Suprabasin-induced breast cancer metastasis. It will help to identify novel diagnostic markers and therapeutic targets for breast metastasis.