共价组装实现多层次手性传递

手性研究对于开发新药、设计新型功能材料以及理解生命体系至关重要。实现手性传递是手性研究中的核心关键之一。目前，手性传递在小分子体系内的研究得到了迅速发展；但是，如何实现并精准调控手性从小分子到宏观材料体系的传递仍然面临巨大挑战。因此，本项目拟以共价组装构筑新型手性有机材料为主线，围绕多层次手性传递、手性表征方法以及手性传递机制开展递进式的研究。在项目组的前期工作基础上，设计合成具有多种（非）手性结构的有机小分子作为构筑基元，通过不同的共价组装方式实现手性从小分子起始基元到宏观材料的传递；建立和拓展宏观手性研究的现代仪器手段，揭示通过共价组装实现手性的渐次传递机制，从而为多层次手性体系的发展提供新的物质发现和理论基础。

Chiral research is essential for the development of new drugs, the design of new functional materials and the understanding of life systems. How to realize chiral transfer is one of the key aspects in chiral research. At present, the research of chiral transfer in 0-dimensional molecule system has been developed rapidly. However, how to achieve and precisely regulate chiral transfer from small molecule to macromaterial system is still facing great challenges. Therefore, this project will focus on the construction of new chiral organic materials by covalent assembly, and carry out progressive research around multi-level chiral transfer, chirality characterizations and chiral transfer mechanism. On the basis of our previous work, small organic molecules with various chiral and achiral structures would be designed and synthesized as building blocks to verify the chiral transfer from small molecules to macro-materials through different covalent assemblies. New characterizations would be established to reveal the chiral transfer through covalent assembly. The results would provide new theoretical basis for the development of multi-level chiral systems.