多烯炔去氢芳构化构筑复杂分子骨架的Domino反应研究

项目通过多烯炔底物经C-C偶联、C-H活化、去氢芳构化途径或芳炔中间体发生氧化还原等方式对一锅法构筑复杂分子骨架的Domino反应进行深入研究。探索去氢芳构化以及基于环加成串联的氧化还原反应形成C-C/C-O/C-Se等键的偶联反应的变化规律，探索钯、钌催化去氢芳构化发生氢转移反应和Wittig试剂、联烯等参与的环加成-氧化-重排-复分解途径合成复杂分子骨架化合物的新方法及其适应性，开发出性能优良的且具有较广泛用途的稠合芳香功能化合物体系。同时深入探索反应底物结构对形成产物结构影响因素及规律性，探索电子、立体因素和区域选择性对环加成芳构化串联反应的影响并揭示其规律性，为去氢芳构化形成氢转移等反应的机制研究及合成多官能化的药物分子设计奠定基础。利用不对称的去氢芳构化Domino反应专一性地构建一些特定类型的天然产物骨架分子开辟崭新的途径。因此项目具有一定的理论意义和潜在应用价值。

The project is based on one pot Domino reaction to construct complex molecular skeleton for further research through multi-enynes substrates by C-C coupling, C-H activation, dehydrogen aromatization or aromatic alkyne intermediates redox. We will develop the rules of dehydrogen aromatization and C-C/C-O/C-Se bomd formation based on cycloaddition coupling reaction by redox reaction. Exploring palladium, ruthenium catalyst dehydrogen aromatization through hydrogen transfer reaction and the cycloaddition - oxidation - rearrangement - double ecomposition reaction with Wittig reagents and dienes to develop a new method of synthesis of complex molecular skeleton compound and its daptability. We expect to develop a fused aromatic compound system of excellent function and extensive use. Meanwhile, the effective factors and the correlative egularity of what substrate structure influence on products strusture are seeken for. Exploring how some factors such as electronic effect, steric effect and the regioselectivity influence the cycloaddition aromatization cascade reaction and reveals its regularity to lay the foundation for the research on mechanism of dehydrogen aromatization reaction by hydrogen transfer and molecular design of synthesis of polyfunctional drugs. We try to explore a new method to construct several specific natural product skeleton molecules by using asymmetric dehydrogen aromatization Domino reaction. Therefore, this research has important theoretical significance and potential application value.