新型持久性有机污染物人体内暴露与甲状腺癌的关联研究

环境污染与健康密切相关。甲状腺癌是影响人体健康的重大疾病之一，近几年来我国甲状腺癌的发病率呈现明显上升趋势。动物实验表明，全氟化合物（PFASs）和短链氯化石蜡（SCCPs）这两类新型持久性有机污染物（POPs）均具有干扰甲状腺的作用，但是缺乏相关人群研究证据，特别是在甲状腺癌发生与新型POPs内暴露的关联方面仍是空白。本项目将在前期已有的研究基础上，在国际上较早地开展甲状腺癌的发生与人体PFASs、SCCPs内暴露的关联。以1：2的比例招募甲状腺癌患病和对照人群900例。分析测定人体血清中PFASs、SCCPs的浓度，研究甲状腺癌患病和对照人群血清中新型POPs的暴露特征以及不同年龄、性别等的差异，分析污染物内暴露对甲状腺激素及血脂代谢的影响。综合人群个体特征和生化指标进行多因素分析，探讨甲状腺癌的发生与人体新型POPs内暴露的关系。研究结果将为阐明环境污染对人体健康的影响提供科学依据。

Environmental pollution is closely related to human health. Thyroid cancer is one of the major diseases that affect human health. The incidence rate of thyroid cancer has been increasing significantly in recent years. Animal experiments show that perfluoroalkyl and polyfluoroalkyl substances (PFASs) and short-chain chlorinated paraffins (SCCPs), two new persistent organic pollutants (POPs), can interfere with thyroid function. However, there is a lack of relevant population research evidence, especially in the correlation between thyroid cancer occurrence and new POPs internal exposure. Based on the previous studies, this project will carry out the association between the occurrence of thyroid cancer and the internal exposure of PFASs and SCCPs in human early in the world. A total of 900 cases of thyroid cancer and control population will be recruited in a ratio of 1:2. Based on the analysis of PFASs and SCCPs in human serum, the exposure characteristics of new POPs and the differences of different ages and genders will be studied, and the effects of internal exposure of pollutants on thyroid hormone and lipid metabolism will be analyzed. By analyzing the individual characteristics and multi factors of biochemical indexes of the population, the relationship between the occurrence of thyroid cancer and the exposure of new POPs in human body will be investigated. The results will provide scientific basis for clarifying the impact of environmental pollution on human health.