近年来环境污染对人体健康造成的潜在危害已引起人们越来越多的关注。本项目针对典型内分泌疾病—糖尿病和甲状腺疾病，采用病例对照的研究方法，在国内较早地开展持久性有机污染物（POPs）在人群中的内暴露与糖尿病和甲状腺疾病的关联研究。通过与山东大学附属千佛山医院合作采集糖尿病和甲状腺疾病患病人群和对照人群志愿者血液样本，在实验室已有工作基础上建立人体血清中POPs的分析方法，对人体中典型POPs—二恶英、多氯联苯、多溴联苯醚和有机氯农药的浓度水平进行分析，研究POPs在患病人群及对照人群中的内暴露特征及差异，探讨糖尿病和甲状腺疾病与人体POPs内暴露的关系。目前，我国对糖尿病和甲状腺疾病与人体POPs内暴露关系的研究还较少，因此通过本项目的研究对于揭示我国环境下人体POPs内暴露对糖尿病和甲状腺疾病的影响具有重要的意义，为掌握我国环境污染对人体健康的影响提供方法学基础和数据支持。

In recent years, the potential harm to human health caused by environmental pollution has attracted more and more attention. This project will carry out an early stage study in China regarding on association of human exposure of persistent organic pollutants (POPs) and typical endocrine disease of diabetes and thyroid diseases by using case-control method. Blood samples were collected from volunteer patients with diabetes, thyroid disease and control population through cooperation with the Qianfoshan Hospital of Shandong University. On the basis of the existing work in the laboratory, the method for the determination of POPs in human serum will be established, and the concentrations of typical POPs- polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) in human serum will be analyzed. The characteristics and differences of POPs exposure in patients and controls will be studied. Further, the relationship between diabetes and thyroid diseases and human exposure of POPs will be investigated. At present, study on the relationship between human exposure of POPs and occurrence of diabetes and thyroid diseases in China was rare. Therefore this project has the important significance to reveal the impact of human exposure of POPs on diabetes and thyroid diseases in China. Also, the results from this project will provide methodological basis and data support to master the influence of environmental pollution on human health in China.