《本经》及中医论著就当归"主咳逆上气"提出了一系列理论，临床与实验研究证实当归对哮喘有确切的治疗作用，但具体机制不清。中医认为痰热耗阴，虚火灼津为痰，上干于肺，宣降失司而致阴虚哮喘；最新研究发现哮喘发作时水通道蛋白(AQPs)的表达出现异常；我们前期的研究结果表明，当归对哮喘模型Th2优势应答有抑制作用。基于中医理论与现代研究，我们提出"当归'主咳逆上气'的机制可能是调节AQPs表达、促进肺水代谢平衡并进一步影响T细胞亚群免疫而防治阴虚哮喘"的工作假说。本课题在复制阴虚哮喘模型的基础上，观察当归防治哮喘过程中对AQPs表达及肺水代谢的影响，同时观察AQPs、黏蛋白分泌与Th2和Th17细胞免疫之间的关系。本课题首次在器官、细胞及分子水平上探讨AQPs表达与T细胞免疫在当归防治阴虚哮喘中的作用及相互关系，为当归防治哮喘提供理论依据。

Benjing and contributions of traditional Chinese medicine(TCM) raise lots of theories to Radix Angelicae Sinensis(RAS) treating asthma and clinical and experimental investigations confirm that RAS do it. But concrete mechanism does not know. Theory of TCM thinks that hot sputum hams Yin, body fluid is burning to sputum by hot, and sputum leads asthma of yin asthenia(AYA). Latest study shows that aquaporins(AQPs) expressions appear abnormality when asthma breaks out and we have proof that RAS can suppress Th2 cell immune to asthma mouse. Based on the theory of TCM and modern studies, we presume that mechanism of RAS treating AYA is that RAS can regulate AQPs expression, promote balance of water metabolism, and influence T cell's immunity. In this item, we study RAS's effectiveness of AQPs expression, water metabolism of lung, and relationship among AQPs, mucoprotein, and T cell's immunity after replicating AYA model. Firstly we approach RAS's actions of AQPs expression and T cell's immunity in treating AYA from organ, cell and molecule and provide theory of RAS treating asthma.