Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema.
Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema.
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DOI：
10.1371/journal.pone.0125329
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Tang X
中科院分区：
文献类型：
--
作者：
Dong N;Xu B;Chu L;Tang X
The aim of the present study was to compare the changes in the levels of 27 aqueous humor cytokines between diabetic patients with macular edema (ME) and diabetic patients without ME. Undiluted aqueous humor samples were obtained from 68 consecutive type 2 diabetic patients without ME and 56 consecutive type 2 diabetic patients with ME. The concentrations of 27 cytokines in the aqueous humor samples were measured using a multiplex bead immunoassay. Compared with diabetic patients without ME, diabetic patients with ME had significantly higher concentrations of IL-1β, IL-6, IL-8, IP-10, MCP-1, and VEGF in the aqueous humor. However, the concentrations of IL-10 and IL-12 were significantly lower in the diabetic patients with ME. The aqueous humor levels of IL-1β, IL-6, IL-8, MCP-1, IP-10, and VEGF were closely correlated with retinal macular thickness, retinal macular volume and the severity of ME. In addition, the aqueous humor levels of IL-10 and IL-12 decreased with increasing the severity of ME. A variety of cytokines associated with inflammation and angiogenesis may contribute to the pathogenesis of diabetic macular edema, and both anti-inflammatory and antiangiogenic agents should be included in the treatment of ME simultaneously.
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DOI：
10.1084/jem.170.6.2081
发表时间：
1989-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fiorentino DF;Bond MW;Mosmann TR
通讯作者：
Mosmann TR
影响因子：
120.7
作者：
Ko, Fang;Vitale, Susan;Chou, Chiu-Fang;Cotch, Mary Frances;Saaddine, Jinan;Friedman, David S.
通讯作者：
Friedman, David S.
影响因子：
158.5
作者：
AIELLO, LP;AVERY, RL;KING, GL
通讯作者：
KING, GL
影响因子：
3.9
作者：
Chou, T-H;Wu, P-C;Kuo, C-N
通讯作者：
Kuo, C-N
影响因子：
2.8
作者：
Dieleman, Myrthe;Wubbels, Rene J.;de Waard, Peter W. T.
通讯作者：
de Waard, Peter W. T.