Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression.
Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression.
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DOI：
10.1371/journal.pone.0003676
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Karry, Rachel
中科院分区：
文献类型：
--
作者：
Ben-Shachar, Dorit;Karry, Rachel
据报道，线粒体功能障碍在精神分裂症、双相情感障碍和重度抑郁症中存在。本研究调查线粒体复合体I异常是否表现出疾病特异性特征。检测了精神分裂症、双相情感障碍、抑郁症和健康人的纹状体和外侧小脑半球标本中复合体I亚单位NDUFV1、NDUFV2和NADUFS1mRNA和蛋白的表达水平，并结合我们以往的数据进行了分析。在复杂的I亚基改变中发现了一种疾病特异性的解剖模式。在前额叶皮质和纹状体观察到精神分裂症特异性的减少。抑郁症组的小脑三个亚单位均持续减少。然而，双相情感障碍组在顶枕叶皮质的表达增加，与精神分裂症患者相似，在小脑中表达减少，但不如抑郁组的一致性。这些结果表明，复杂I病理的神经解剖学模式与这些精神障碍的临床症状的差异和相似之处相似。
Mitochondrial dysfunction was reported in schizophrenia, bipolar disorderand major depression. The present study investigated whether mitochondrial complex I abnormalities show disease-specific characteristics. mRNA and protein levels of complex I subunits NDUFV1, NDUFV2 and NADUFS1, were assessed in striatal and lateral cerebellar hemisphere postmortem specimens and analyzed together with our previous data from prefrontal and parieto-occipital cortices specimens of patients with schizophrenia, bipolar disorder, major depression and healthy subjects. A disease-specific anatomical pattern in complex I subunits alterations was found. Schizophrenia-specific reductions were observed in the prefrontal cortex and in the striatum. The depressed group showed consistent reductions in all three subunits in the cerebellum. The bipolar group, however, showed increased expression in the parieto-occipital cortex, similar to those observed in schizophrenia, and reductions in the cerebellum, yet less consistent than the depressed group. These results suggest that the neuroanatomical pattern of complex I pathology parallels the diversity and similarities in clinical symptoms of these mental disorders.
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