African Swine Fever Virus Interaction with Host Innate Immune Factors.
African Swine Fever Virus Interaction with Host Innate Immune Factors.
复制标题
DOI：
10.3390/v15061220
复制
发表时间：
2023-05-23
期刊：
影响因子：
--
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Afe AE;Shen ZJ;Guo X;Zhou R;Li K
非洲猪瘟病毒(ASFV)因其100%的死亡率而对养猪业造成不利影响。这种情况的特点是体温升高，出血和家猪共济失调，而疣猪和扁虱仍然没有症状，尽管它们是病毒的天然宿主。培育抗ASFV的猪是根除这种疾病的一种有希望的解决方案。ASFV使用几种机制来耗尽宿主的抗病毒反应。本文综述了ASFV蛋白与宿主天然免疫的相互作用以及病毒蛋白所包含的抑制和诱导不同信号通路的各种机制，如cGAS-STING、NF-κB、肿瘤生长因子-β(TGFR-β)、泛素化、病毒抑制细胞凋亡和抵抗ASFV感染。并对培育抗ASFV家猪的前景进行了讨论。
African swine fever virus (ASFV) adversely affects pig farming owing to its 100% mortality rate. The condition is marked by elevated body temperature, bleeding, and ataxia in domestic pigs, whereas warthogs and ticks remain asymptomatic despite being natural reservoirs for the virus. Breeding ASFV-resistant pigs is a promising solution for eradicating this disease. ASFV employs several mechanisms to deplete the host antiviral response. This review explores the interaction of ASFV proteins with innate host immunity and the various types of machinery encompassed by viral proteins that inhibit and induce different signaling pathways, such as cGAS-STING, NF-κB, Tumor growth factor-beta (TGF-β), ubiquitination, viral inhibition of apoptosis, and resistance to ASFV infection. Prospects for developing a domestic pig that is resistant to ASFV are also discussed.
登录
查看更多内容
缺乏CD163的猪富含清道夫受体的富含半胱氨酸的结构域5具有对猪生殖和呼吸综合征病毒1感染的抗性。
影响因子：
5.4
作者：
Burkard C;Opriessnig T;Mileham AJ;Stadejek T;Ait-Ali T;Lillico SG;Whitelaw CBA;Archibald AL
通讯作者：
Archibald AL
影响因子：
5.2
作者：
通讯作者：
--
影响因子：
4.4
作者：
Chen, Huan;Wang, Zhenzhong;Gao, Xiaoyu;Lv, Jiaxuan;Hu, Yongxin;Jung, Yong-Sam;Zhu, Shanyuan;Wu, Xiaodong;Qian, Yingjuan;Dai, Jianjun
通讯作者：
Dai, Jianjun
影响因子：
3.7
作者：
de Oliveira, Remi Pereira;Hutet, Evelyne;Le Potier, Marie-Frederique
通讯作者：
Le Potier, Marie-Frederique
影响因子：
5.4
作者：
Dodantenna, Niranjan;Ranathunga, Lakmal;Chathuranga, W. A. Gayan;Weerawardhana, Asela;Cha, Ji-Won;Subasinghe, Ashan;Gamage, Nuwan;Haluwana, D. K.;Kim, YongKwan;Jheong, WeonHwa;Poo, Haryoung;Lee, Jong-Soo
通讯作者：
Lee, Jong-Soo