Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
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DOI：
10.1002/ajmg.b.32087
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发表时间：
2012-10
影响因子：
2.8
通讯作者：
Zeggini, Eleftheria
中科院分区：
文献类型：
--
作者：
Boraska, Vesna;Davis, Oliver S. P.;Cherkas, Lynn F.;Helder, Sietske G.;Harris, Juliette;Krug, Isabel;Pei-Chi Liao, Thomas;Treasure, Janet;Ntalla, Ioanna;Karhunen, Leila;Keski-Rahkonen, Anna;Christakopoulou, Danai;Raevuori, Anu;Shin, So-Youn;Dedoussis, George V.;Kaprio, Jaakko;Soranzo, Nicole;Spector, Tim D.;Collier, David A.;Zeggini, Eleftheria
关键词：
进食障碍（ED）是常见的，复杂的精神疾病，被认为是由遗传和环境因素引起的。他们有许多共同的症状，行为和个性特征，可能具有重叠的遗传性。本研究的目的是对六种艾德表型进行全基因组关联扫描（GWAS），这些表型包括饮食失调量表2中的三种症状特征[瘦身动力（DT）、身体不满意（BD）和贪食症]、体重波动症状、不吃早餐行为和儿童强迫性人格障碍特征（CHIRP）。调查的特征来自TwinsUK人群队列完成的标准化自我报告问卷。我们在TwinsUK发现数据集中的六种感兴趣的表型中测试了283，744个直接分型的SNP，并在两个独立的欧洲血统队列中使用两阶段复制策略对来自不同阶层的后续信号进行了测试。我们共对2,698名DT患者、2,680名BD患者、2789名（821例病例/1，968例对照）贪食症，1，360例（633例/727对照）儿童强迫性人格障碍特质，2773（761例/2，012名对照），体重波动症状2，967例（798例/2，169名对照）。在对6种ED相关表型的GWAS分析中，我们检测到8种遗传变异与P < 10−5的关联。显示出相关证据的遗传变异先前与几种精神疾病和ED相关表型相关。我们的研究表明，将需要更大规模的合作研究，以实现必要的权力，以检测基因座的ED相关性状。© 2012 Wiley Periodicals，Inc.
Eating disorders (EDs) are common, complex psychiatric disorders thought to be caused by both genetic and environmental factors. They share many symptoms, behaviors, and personality traits, which may have overlapping heritability. The aim of the present study is to perform a genome-wide association scan (GWAS) of six ED phenotypes comprising three symptom traits from the Eating Disorders Inventory 2 [Drive for Thinness (DT), Body Dissatisfaction (BD), and Bulimia], Weight Fluctuation symptom, Breakfast Skipping behavior and Childhood Obsessive-Compulsive Personality Disorder trait (CHIRP). Investigated traits were derived from standardized self-report questionnaires completed by the TwinsUK population-based cohort. We tested 283,744 directly typed SNPs across six phenotypes of interest in the TwinsUK discovery dataset and followed-up signals from various strata using a two-stage replication strategy in two independent cohorts of European ancestry. We meta-analyzed a total of 2,698 individuals for DT, 2,680 for BD, 2,789 (821 cases/1,968 controls) for Bulimia, 1,360 (633 cases/727 controls) for Childhood Obsessive-Compulsive Personality Disorder trait, 2,773 (761 cases/2,012 controls) for Breakfast Skipping, and 2,967 (798 cases/2,169 controls) for Weight Fluctuation symptom. In this GWAS analysis of six ED-related phenotypes, we detected association of eight genetic variants with P < 10−5. Genetic variants that showed suggestive evidence of association were previously associated with several psychiatric disorders and ED-related phenotypes. Our study indicates that larger-scale collaborative studies will be needed to achieve the necessary power to detect loci underlying ED-related traits. © 2012 Wiley Periodicals, Inc.
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