Biomarker profiles and their relation to clinical variables in mild cognitive impairment
Biomarker profiles and their relation to clinical variables in mild cognitive impairment
复制标题
轻度认知障碍的生物标志物概况及其与临床变量的关系
作者：
S. Schoonenboom;Pieter Jelle Visser;Cjj Mulder;Jaap Lindeboom;E. V. Elk;G. J. V. Kamp;P. Scheltens
该研究的目的是根据其生物标志物特征，比较不同阿尔茨海默病（AD）风险的MCI患者之间的临床变量。在39例MCI患者中，54%的患者脑脊液（CSF）中Aβ42低而tau高（高风险），26%的患者CSF Aβ42低或CSF tau高（中风险），20%的患者CSF Aβ42和tau正常（低风险）。高风险和中风险受试者在情景记忆、执行功能和临床前AD量表（PAS）（结合了一组临床参数）方面均不同于低风险组。高风险受试者与中等风险受试者无差异。Aβ42水平与MTA和PAS评分相关，tau水平与情景记忆相关。这些相关性表明，与其他AD标志物相比，生物标志物不是独立的。纵向研究是必要的，以解释生物标志物，成像和神经心理学标志物之间的相关性。
The aim of the study was to compare clinical variables between MCI patients at different risk for Alzheimer’s disease (AD) according to their biomarker profile. Fifty-four percent out of 39 MCI patients had a low Aβ42 and high tau in cerebrospinal fluid (CSF) (high-risk), 26% either a low CSF Aβ42 or high CSF tau (intermediate-risk) and 20% a normal CSF Aβ42 and tau (low-risk). Both high- and intermediate-risk subjects differed from the low-risk group in episodic memory, executive functions and the preclinical AD scale (PAS), which combines a set of clinical parameters. Subjects at high risk did not differ from subjects with an intermediate risk. Aβ42 levels correlated with the MTA and PAS scores, tau levels with episodic memory. These correlations suggest that the biomarkers are not independent when compared to the other AD markers. Longitudinal studies are necessary to interpret the correlations between biomarkers, imaging, and neuropsychological markers.
影响因子：
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作者：
Grundman, M;Petersen, RC;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
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作者：
Guillozet, AL;Weintraub, S;Mesulam, MM
通讯作者：
Mesulam, MM