Cartilage morphology and T1ρ and T2 quantification in ACL-reconstructed knees: a 2-year follow-up.
Cartilage morphology and T1ρ and T2 quantification in ACL-reconstructed knees: a 2-year follow-up.
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DOI：
10.1016/j.joca.2013.05.010
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发表时间：
2013-08
影响因子：
7
通讯作者：
Li, X.
中科院分区：
文献类型：
--
作者：
Su, F.;Hilton, J. F.;Nardo, L.;Wu, S.;Liang, F.;Link, T. M.;Ma, C. B.;Li, X.
关键词：
描述急性前交叉韧带（ACL）损伤后重建后2年内相对于对照组和纵向使用定量MRI评估的软骨基质和形态变化。研究了15例急性ACL损伤患者和16例健康志愿者，他们的人口统计学特征相似，但没有骨关节炎或膝关节损伤史。在基线（ACL重建前），用3.0 T MR扫描仪对每个参与者的受伤膝关节进行成像;患者的膝关节在ACL重建后1年和2年重新成像。在膝关节的亚隔室内量化全层、浅层和深层的软骨T1ρ和T2值以及全层的软骨厚度。在胫骨后外侧软骨中，ACL损伤膝关节的T1ρ值在基线时显著高于对照膝关节，并且在ACL重建后2年未完全恢复。ACL损伤膝关节内侧胫股软骨的T1ρ值在2年研究中增加，与对照膝关节相比显著升高。与对照膝关节相比，2年随访时股骨内侧髁中央软骨的T2值显著升高。胫骨外侧后部的软骨明显变薄，而股骨内侧中部的软骨明显比对照组厚。在两年内，内侧半月板后角损伤的患者胫股软骨负重区的T1ρ值显著高于对照组，而没有内侧半月板撕裂的患者则没有。定量MRI为定量评价急性ACL损伤和重建后软骨基质和形态的早期变化提供了有力的工具，这些变化可能与此类关节创伤后骨关节炎的发展有关。
To describe cartilage matrix and morphology changes, assessed using quantitative MRI, after acute anterior cruciate ligament (ACL) injury relative to controls and longitudinally during 2 years following reconstruction. Fifteen patients with acute ACL injuries and sixteen healthy volunteers with a similar demographic profile but no history of osteoarthritis or knee injury were studied. The injured knee of each participant was imaged with a 3.0 T MR scanner at baseline (prior to ACL reconstruction); patients’ knees were re-imaged 1- and 2-years after ACL reconstruction. Cartilage T1ρ and T2 values in full thickness, superficial layers, and deep layers, and cartilage thickness of the full layer were quantified within subcompartments of the knee joint. In the posterolateraltibial cartilage, T1ρ values were significantly higher in ACL-injured knees than control knees at baseline and were not fully recovered at the 2-year after ACL reconstruction. T1ρ values of medial tibiofemoral cartilage in ACL-injured knees increased over the 2-year study and were significantly elevated compared to that of the control knees. T2 values in cartilage of the central aspect of the medial femoral condyle at the 2-year follow-up were significantly elevated compared with control knees. Cartilage in the posterior regions of the lateral tibia was significantly thinner, while cartilage in the central aspect of the medial femur was significantly thicker than that of controls. Patients with lesions in the posterior horn of the medial meniscus exhibited significantly higher T1ρ values in weight-bearing regions of the tibiofemoral cartilage than that of control subjects over the two year period, whereas patients without medial meniscal tears did not. Quantitative MRI provides powerful in vivo tools to quantitatively evaluate early changes of cartilage matrix and morphology after acute ACL injury and reconstruction, which may possibly relate to the development of post-traumatic osteoarthritis in such joints.
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