Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients.
Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients.
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DOI：
10.1038/s41598-021-92045-x
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发表时间：
2021-06-23
影响因子：
4.6
通讯作者：
Feldt-Rasmussen U
中科院分区：
文献类型：
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作者：
Bliddal S;Banasik K;Pedersen OB;Nissen J;Cantwell L;Schwinn M;Tulstrup M;Westergaard D;Ullum H;Brunak S;Tommerup N;Feenstra B;Geller F;Ostrowski SR;Grønbæk K;Nielsen CH;Nielsen SD;Feldt-Rasmussen U
有关新冠肺炎患者住院后持续出现症状的报道引发了人们对“长期冠状病毒病”综合征的担忧。本研究旨在通过聚合酶链式反应确定新冠肺炎确诊的非住院患者中急性持续性症状的患病率及其危险因素。我们对通过丹麦民事登记系统确定的非住院参与者进行了一项队列研究，采用SARS-CoV-2阳性聚合酶链式反应检测和可用的生物库样本。参与者收到了一份关于人口统计学和新冠肺炎相关症状的数字问卷。持续性症状：症状>； 4周(敏感性分析>； 12周)。我们纳入了445名参与者，其中34%没有症状。最常见的急性症状是疲劳、头痛和打喷嚏，而疲劳和嗅觉和味觉下降是最严重的。在198名有症状的参与者中，36%的人报告了持续性症状，最常见的是疲劳、记忆力和注意力困难，并进行了4周的随访>； 。持续性症状的危险因素包括女性(女性44%对男性24%，优势比2.7，95%可信区间1.4~5.1，p = 0.003)和体重指数(优势比1.1，95%可信区间1.0~1.2，p = 0.001)。总而言之，在未住院的聚合酶链式反应确诊的新冠肺炎患者中，三分之一没有症状，而有症状的参与者中有三分之一有持续性症状，这说明了疾病表现的异质性。这些发现应该被考虑到与新冠肺炎相关的医疗规划和政策制定中。
Reports of persistent symptoms after hospitalization with COVID-19 have raised concern of a “long COVID” syndrome. This study aimed at determining the prevalence of and risk factors for acute and persistent symptoms in non-hospitalized patients with polymerase chain reaction (PCR) confirmed COVID-19. We conducted a cohort study of non-hospitalized participants identified via the Danish Civil Registration System with a SARS-CoV-2-positive PCR-test and available biobank samples. Participants received a digital questionnaire on demographics and COVID-19-related symptoms. Persistent symptoms: symptoms > 4 weeks (in sensitivity analyses > 12 weeks). We included 445 participants, of whom 34% were asymptomatic. Most common acute symptoms were fatigue, headache, and sneezing, while fatigue and reduced smell and taste were most severe. Persistent symptoms, most commonly fatigue and memory and concentration difficulties, were reported by 36% of 198 symptomatic participants with follow-up > 4 weeks. Risk factors for persistent symptoms included female sex (women 44% vs. men 24%, odds ratio 2.7, 95% CI 1.4–5.1, p = 0.003) and BMI (odds ratio 1.1, 95% CI 1.0–1.2, p = 0.001). In conclusion, among non-hospitalized PCR-confirmed COVID-19 patients one third were asymptomatic while one third of symptomatic participants had persistent symptoms illustrating the heterogeneity of disease presentation. These findings should be considered in health care planning and policy making related to COVID-19.
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影响因子：
5.1
作者：
Billi AC;Kahlenberg JM;Gudjonsson JE
通讯作者：
Gudjonsson JE
影响因子：
7.2
作者：
Hopkins, Claire;Surda, Pavol;Kumar, Nirmal
通讯作者：
Kumar, Nirmal
影响因子：
2.8
作者：
Ladds E;Rushforth A;Wieringa S;Taylor S;Rayner C;Husain L;Greenhalgh T
通讯作者：
Greenhalgh T
影响因子：
33.9
作者：
Chow, Nancy;Fleming-Dutra, Katherine;Ussery, Emily
通讯作者：
Ussery, Emily
DOI：
10.1016/s0140-6736(20)32705-7
发表时间：
2021-02-06
期刊：
Lancet (London, England)
影响因子：
--
作者：
Gorna R;MacDermott N;Rayner C;O'Hara M;Evans S;Agyen L;Nutland W;Rogers N;Hastie C
通讯作者：
Hastie C