[Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects].
[Regenerative therapy for tendon and ligament disorders in horses. Terminology, production, biologic potential and in vitro effects].
复制标题
[马肌腱和韧带疾病的再生疗法。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
P. Stadler
中科院分区：
文献类型：
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作者：
F. Geburek;P. Stadler
马肌腱损伤的常规治疗导致愈合过程不令人满意，通常导致相对较高的复发率。因此，近年来，在体外和实验室动物中对所谓的再生疗法进行了科学研究。这些包括理想地导致替代组织形成的物质，与低质量的瘢痕相比，替代组织具有与原始完整肌腱相似的功能特性。目前，大量不同的底物可商购获得，或者可以在试剂盒的帮助下在实践中生产。目前的知识生产和再生潜力的有核细胞，如干细胞从骨髓和脂肪组织，血液制品PRP（血小板丰富的血浆），ACP（自体条件血浆），ACS（自体条件血清）和支架物质UBM（膀胱基质）。最后，一些生长因子和基因治疗的潜力被认为是。目前，认为肌腱组织的再生是由支架、生长因子和细胞的复杂相互作用促进的。目前，只有很少的研究可以对这些物质进行比较。再生基质对活马肌腱的影响的研究在其他地方介绍。
Conventional treatments of equine tendon injuries lead to an unsatisfactory healing process that usually results in a relatively high recurrence rate. Therefore, in recent years so-called regenerative therapeutics were studied scientifically in vitro and in laboratory animals. These include substances that ideally lead to the formation of replacement tissue, which in contrast to the low quality scar, has similar functional properties as the original intact tendon. Currently, a plethora of different substrates is either commercially available or can be produced in practice with the help of kits. The current knowledge on the production and the regenerative potential of nucleated cells like stem cells from bone marrow and fat tissue, of the blood products PRP (platelet rich plasma), ACP (autologous conditioned plasma), ACS (autologous conditioned serum) and of the scaffold substance UBM (urinary bladder matrix) are presented. Finally, the potential of some growth factors and of gene therapy is considered. Currently, it is assumed that the regeneration of tendon tissue is promoted by a complex interaction of scaffolds, growth factors and cells. At present, only very few studies are available which allow a comparison between these substances. Studies on the effect of regenerative substrates on tendons in live horses are presented elsewhere.
影响因子：
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作者：
Brennan, Ellen P.;Reing, Janet;Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.