Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve.
Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve.
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具有二尖瓣和三尖瓣主动脉瓣的升胸主动脉瘤血流动力学和壁应力的差异。
DOI：
10.1016/j.jbiomech.2013.03.029
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发表时间：
2013-06-21
影响因子：
2.4
通讯作者：
Vorp DA
中科院分区：
文献类型：
--
作者：
Pasta S;Rinaudo A;Luca A;Pilato M;Scardulla C;Gleason TG;Vorp DA
升主动脉瘤的主动脉夹层(AOD)始于施加在瘤壁上的血流动力学载荷，克服了将弹力层粘合在一起的粘附力。对来自二尖瓣或三尖瓣患者的ATA进行平行耦合的双向流固相互作用(FSI)分析，以评估血流动力学预测因子和给予动脉瘤扩大和AOD的壁应力。结果显示，BAVATAAS的动脉瘤中心呈左旋回流伴较慢的螺旋运动，而TAVATAAS的血流向升主动脉前外侧略有偏转。血压和壁面切应力是预测动脉瘤扩张的关键血流动力学指标，它们的不同可能与主动脉瓣的形态解剖有关。我们还观察到动脉瘤样主动脉上不连续的壁应力，它被建模为具有两个弹性层的复合材料(即血管结构组织的不均质性)。这种应力分布是由于主动脉各层弹性材料性质的差异造成的。壁应力分布显示AOD恰好位于窦管交界处上方。此外，血流异常和较低的弹性材料特性可能是BAV个体固有的，使动脉瘤容易发生AOD。
The aortic dissection (AoD) of an ascending thoracic aortic aneurysm (ATAA) initiates when the hemodynamic loads exerted on the aneurysmal wall overcome the adhesive forces holding the elastic layers together. Parallel coupled, two-way fluid–structure interaction (FSI) analyses were performed on patient-specific ATAAs obtained from patients with either bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) to evaluate hemodynamic predictors and wall stresses imparting aneurysm enlargement and AoD. Results showed a left-handed circumferential flow with slower-moving helical pattern in the aneurysm's center for BAV ATAAs whereas a slight deviation of the blood flow toward the anterolateral region of the ascending aorta was observed for TAV ATAAs. Blood pressure and wall shear stress were found key hemodynamic predictors of aneurysm dilatation, and their dissimilarities are likely associated to the morphological anatomy of the aortic valve. We also observed discontinues, wall stresses on aneurysmal aorta, which was modeled as a composite with two elastic layers (i.e., inhomogeneity of vessel structural organization). This stress distribution was caused by differences on elastic material properties of aortic layers. Wall stress distribution suggests AoD just above sinotubular junction. Moreover, abnormal flow and lower elastic material properties that are likely intrinsic in BAV individuals render the aneurysm susceptible to the initiation of AoD.
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影响因子：
14
作者：
Hope, Michael D.;Hope, Thomas A.;Higgins, Charles B.
通讯作者：
Higgins, Charles B.
影响因子：
5
作者：
Abbara, Suhny;Pena, Antonio J.;Brady, Thomas J.
通讯作者：
Brady, Thomas J.
DOI：
10.1186/1532-429x-12-4
发表时间：
2010-01-13
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
den Reijer PM;Sallee D 3rd;van der Velden P;Zaaijer ER;Parks WJ;Ramamurthy S;Robbie TQ;Donati G;Lamphier C;Beekman RP;Brummer ME
通讯作者：
Brummer ME
影响因子：
24
作者：
Cripe, L;Andelfinger, G;Benson, DW
通讯作者：
Benson, DW
影响因子：
4.6
作者：
Nathan, Derek P.;Xu, Chun;Jackson, Benjamin M.
通讯作者：
Jackson, Benjamin M.