Evidence for induction of a phosphate appetite in juvenile rats.
Evidence for induction of a phosphate appetite in juvenile rats.
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诱导幼年大鼠磷酸盐食欲的证据。
DOI：
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发表时间：
1998
影响因子：
--
通讯作者：
S. Mulroney
中科院分区：
文献类型：
--
作者：
J. Sweeny;H. Edward Seibert;C. Woda;Jay Schulkin;A. Haramati;S. Mulroney
本研究探讨了膳食磷酸盐（Pi）限制是否会刺激幼年大鼠对Pi的食欲，而幼年大鼠通常对生长有高代谢的Pi需求。将幼年Wistar大鼠置于单独的笼中，不受限制地获得自来水和低（LPD，0.02%Pi）或正常Pi饮食（NPD，0.6%Pi）7天。在第8天，两组大鼠无限制地接触0.3 M磷酸钾水（PiH 2 O）溶液，再持续8天。饲喂LPD的大鼠比饲喂NPD的大鼠多消耗70-100%的PiH_2 O（P < 0.001）。PiH 2 O摄入量的增加导致在第8-15天喂食LPD的大鼠的生长速率显著上升。LPD仅2天后即可诱导类似的Pi摄入，并且与血浆和脑脊液（CSF）Pi水平显着降低相关;尽管摄入了大量PiH 2 O，但在Pi限制期间，这些水平仍然较低。此外，肾脏的适应，以提高Pi重吸收（TmPi）在Pi剥夺仍然升高，尽管增强PiH 2 O摄入。补充高磷饮食迅速淬灭的PiH 2 O食欲，并与恢复血浆和CSF的Pi水平。这些发现表明，可能通过降低血浆和CSF Pi水平，可以诱导幼龄大鼠对Pi的食欲。这种行为反应可以作为维持动物生长和发育所需的足够Pi供应的额外机制。
This study examined whether dietary phosphate (Pi) restriction stimulates an appetite for Pi in the juvenile rat, which normally has a high metabolic Pi demand for growth. Juvenile Wistar rats were placed in individual cages with unrestricted access to tap water and a low (LPD, 0.02% Pi) or normal Pi diet (NPD, 0.6% Pi) for 7 days. On day 8, both groups of rats were given unlimited access to a solution of 0.3 M potassium phosphate water (PiH2O) for 8 additional days. Rats fed LPD consumed 70-100% more PiH2O then those rats fed NPD (P < 0.001). The increase in PiH2O intake resulted in a marked rise in the growth rate of rats fed LPD during days 8-15. A similar Pi intake was inducible after only 2 days of LPD and was associated with significant reductions in both plasma and cerebrospinal fluid (CSF) Pi levels; these levels remained low throughout Pi restriction, despite a significant PiH2O intake. Furthermore, the renal adaptation to enhance Pi reabsorption (TmPi) during Pi deprivation remained elevated despite enhanced PiH2O intake. Replenishment with a high-Pi diet rapidly quenched the PiH2O appetite and was associated with restoration of both plasma and CSF Pi levels. These findings suggest that an appetite for Pi can be induced in juvenile rats, perhaps through lowered plasma and CSF Pi levels. This behavioral response may serve as an additional mechanism to maintain an adequate supply of Pi necessary for growth and development of the animal.
大鼠肾小管磷酸盐重吸收能力的发育变化。
DOI：
10.1152/ajprenal.1988.255.2.f287
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
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作者：
Haramati,A;Mulroney,SE;Webster,SK
通讯作者：
Webster,SK
发育过程中肾脏对膳食磷酸盐变化的适应。
DOI：
10.1152/ajprenal.1990.258.6.f1650
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Mulroney,SE;Haramati,A
通讯作者：
Haramati,A
在幼年大鼠中，内毒素诱导的生长轴抑制是由白细胞介素 1β 和促肾上腺皮质激素释放因子介导的。
DOI：
10.1210/endo.136.8.7628373
发表时间：
1995
期刊：
Endocrinology.
影响因子：
--
作者：
Peisen,JN;McDonnell,KJ;Mulroney,SE;Lumpkin,MD
通讯作者：
Lumpkin,MD