High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee.
High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee.
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富含不同脂肪酸的高脂饮食会诱发蜜蜂肥胖并扰乱其肠道微生物群。
DOI：
10.3390/ijms22020834
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发表时间：
2021-01-15
影响因子：
5.6
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Wang X;Zhong Z;Chen X;Hong Z;Lin W;Mu X;Hu X;Zheng H
HFD（高脂肪饮食）诱导肥胖和代谢紊乱，这与肠道微生物群谱的改变有关。然而，这一过程的潜在分子机制尚不清楚。在这项研究中，我们使用简单的模式生物蜜蜂来探索不同数量和类型的膳食脂肪如何影响宿主代谢和肠道微生物群。过量的膳食脂肪，尤其是棕榈油，会导致蜜蜂体重增加、存活率降低、高血糖和脂肪堆积。然而，在高脂肪饮食中饲养的无微生物蜜蜂并没有显著改变它们的表型。棕榈油和大豆油中不同的脂肪酸组成改变了蜜蜂体内的脂质谱。值得注意的是，膳食脂肪在转录水平上调节脂质代谢和免疫相关基因的表达。基因集富集分析表明，不同膳食脂肪的蜜蜂肠道的生物学过程，包括转录因子、胰岛素分泌、Toll和Imd信号通路，都有显著差异。此外，高脂肪饮食增加了吉利亚氏菌的相对丰度，而棕榈油组的巴尔通体水平显著降低。本研究建立了一种新的蜜蜂模型来研究膳食脂肪、肠道微生物群和宿主代谢之间的串扰。
HFD (high-fat diet) induces obesity and metabolic disorders, which is associated with the alteration in gut microbiota profiles. However, the underlying molecular mechanisms of the processes are poorly understood. In this study, we used the simple model organism honey bee to explore how different amounts and types of dietary fats affect the host metabolism and the gut microbiota. Excess dietary fat, especially palm oil, elicited higher weight gain, lower survival rates, hyperglycemic, and fat accumulation in honey bees. However, microbiota-free honey bees reared on high-fat diets did not significantly change their phenotypes. Different fatty acid compositions in palm and soybean oil altered the lipid profiles of the honey bee body. Remarkably, dietary fats regulated lipid metabolism and immune-related gene expression at the transcriptional level. Gene set enrichment analysis showed that biological processes, including transcription factors, insulin secretion, and Toll and Imd signaling pathways, were significantly different in the gut of bees on different dietary fats. Moreover, a high-fat diet increased the relative abundance of Gilliamella, while the level of Bartonella was significantly decreased in palm oil groups. This study establishes a novel honey bee model of studying the crosstalk between dietary fat, gut microbiota, and host metabolism.
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影响因子：
3.7
作者：
Kim KA;Gu W;Lee IA;Joh EH;Kim DH
通讯作者：
Kim DH
影响因子：
1.5
作者：
Ghosh, Sampat;Jung, Chuleui;Meyer-Rochow, Victor Benno
通讯作者：
Meyer-Rochow, Victor Benno
饮食脂肪源的组成形状形状肠道菌群结构和改变小鼠脂肪组织中的炎症介质。
DOI：
10.1177/0148607113486931
发表时间：
2013-11
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
--
作者：
Huang EY;Leone VA;Devkota S;Wang Y;Brady MJ;Chang EB
通讯作者：
Chang EB
影响因子：
29
作者：
Birse RT;Choi J;Reardon K;Rodriguez J;Graham S;Diop S;Ocorr K;Bodmer R;Oldham S
通讯作者：
Oldham S
DOI：
10.1073/pnas.1517375112
发表时间：
2015-12-22
影响因子：
11.1
作者：
Arien, Yael;Dag, Arnon;Shafir, Sharoni
通讯作者：
Shafir, Sharoni