Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
Noncoding RNA as therapeutic targets for hepatocellular carcinoma.
复制标题
非编码RNA作为肝细胞癌的治疗靶标。
DOI：
10.1055/s-0034-1397350
复制
发表时间：
2015-02
影响因子：
4.2
通讯作者：
Patel T
中科院分区：
文献类型：
--
作者：
George J;Patel T
近年来的研究表明，非编码RNA（ncRNA）参与了肝细胞癌（HCC）的发生和发展。这些RNA基因可能参与各种病理生物学过程，如细胞增殖、凋亡、血管生成、侵袭和转移。在几项研究中已经描述了由失调的表观遗传、转录或转录后活性引起的ncRNA的异常表达。ncRNA由一组高度多样化的转录物组成，包括microRNA（miRNA）和长非编码RNA（lncRNA）以及几种其他类型的RNA基因。了解ncRNA促进肝癌发生的分子机制可能有助于设计基于ncRNA的HCC治疗方法。这篇综述提供了一个基于新出现的证据的miRNAs和lncRNAs的发病机制和进展的HCC的贡献作用的治疗应用的前景。此外，在HCC中表达失调的ncRNA可作为潜在的预后或诊断标志物。
Recent studies have suggested that non-coding RNAs (ncRNAs) contribute to the pathogenesis and progression of hepatocellular carcinoma (HCC). These RNA genes may be involved in various pathobiological processes such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Aberrant expression of ncRNA resulting from deregulated epigenetic, transcriptional or post-transcriptional activity has been described in several studies. ncRNAs comprise of a highly diverse group of transcripts that include microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as well as several other types of RNA genes. Understanding the molecular mechanisms by which ncRNA contribute to hepatocarcinogenesis may enable the design of ncRNA based therapeutics for HCC. This review provides a perspective on therapeutic applications based on the emerging evidence of a contributory role of miRNAs and lncRNAs to the pathogenesis and progression of HCC. In addition, ncRNA that are deregulated in expression in HCC may have utility as potential prognostic or diagnostic markers.
登录
查看更多内容
影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
4
作者：
Chen, Hongyuan;Miao, Ruizheng;Peng, Zhihai
通讯作者：
Peng, Zhihai
影响因子：
82.9
作者：
Bonci, Desiree;Coppola, Valeria;De Maria, Ruggero
通讯作者：
De Maria, Ruggero
影响因子：
2.5
作者：
Chun, Jae Min;Kwon, Hyung Jun;Hwang, Yoon Jin
通讯作者：
Hwang, Yoon Jin