Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
复制标题
DOI：
10.1007/s00432-011-1007-z
复制
发表时间：
2011-09
影响因子：
3.6
通讯作者：
Caglar, Cakar
中科院分区：
文献类型：
--
作者：
Paksoy, Mustafa;Hardal, Umit;Caglar, Cakar
本研究旨在探讨组织蛋白酶D （Cath-D）和e -钙粘蛋白（E-Cad）在肿瘤组织和颈部淋巴结转移中的表达水平。这种尝试应该是为了确定新的因素，一个可能是有用的预测临床行为。在这项研究中，我们调查了56例选择的患者喉部和颈部解剖标本中E-Cad和cat - d的死亡率。喉部标本经ECad和cat - d免疫组化染色。E-Cad的免疫反应性分为阳性（75%及以上）、降低（25-75%）和阴性（低于25%）。免疫反应性分类为cat - d：染料吸收率高于50%评估为阳性，吸收率低于50%评估为阴性。我们比较了标本中有无颈部淋巴结转移的E-Cad组和cat - d组的死亡率。41%的患者有颈部转移，标本中E-Cad阴性者为55.6%，降低者为40.6%，阳性者为33.3%。Cath-D表达阴性的患者发生颈部转移的比例为35.4%，Cath-D表达阳性的患者发生颈部转移的比例为75%。E-Cad降低组颈部转移率高于阳性组。Cath-D阳性组颈结转移率明显高于阴性组。ct - d和E-Cad论文可用于识别颈部淋巴结受累。Cath-D表达水平比E-Cad水平更能预测LSCC颈部淋巴结转移的可能性。
The aim of this study was to investigate the relation between Cathepsin D (Cath-D) and E-Cadherin (E-Cad) expression levels in tumor tissue and neck lymph node metastasis. This attempt should be made to identify new factors that one could be useful in predicting clinical behavior. In this study, we investigated rates of dying for E-Cad and Cath-D in paraphin blocks of larynx and neck dissection specimens taken from 56 selected patients. Laryngeal specimens dyed by ECad and Cath-D immunohistochemically. Immunoreactivity classified for E-Cad as positive (75% and above), reduced (25–75%) and negative (below 25%). Immunoreactivity classified for Cath-D:dye absorption rates higher than 50% evaluated positive and absorption rates lower than 50% evaluated negative. We compared the rates of dying for E-Cad and Cath-D groups to with or without neck lymph node metastasis in specimens. Neck metastasis were found in 41% of patients, in 55.6% of patients, if the E-Cad was negative, 40.6% if it was reduced, 33.3% if it was positive in specimens. The neck metastasis was found in 35.4% of patients with Cath-D expression negative, while 75% of patients was found with Cath-D expression positive. Neck metastasis was found higher in E-Cad reduced group than positive group. Neck node metastasis was significantly higher in Cath-D positive group than Cath-D negative group. Cath-D and E-Cad essays may useful in identifying neck lymph node involvement. Cath-D expression levels are more in this predictive factor than E-Cad levels for possibility of neck lymph node metastasis in LSCC.
登录
查看更多内容
影响因子：
2.6
作者：
Liu, M;Lawson, G;Remacle, M
通讯作者：
Remacle, M
影响因子：
6.2
作者：
Chang, HW;Chow, V;Yuen, APW
通讯作者：
Yuen, APW
影响因子：
254.7
作者：
Jemal, A;Tiwari, RC;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1016/0360-3016(87)90186-6
发表时间：
1987-08-01
影响因子：
7
作者：
HAHN, SS;SPAULDING, CA;CONSTABLE, WC
通讯作者：
CONSTABLE, WC
影响因子：
4.8
作者：
Diniz-Freitas, M;García-Caballero, T;García-García, A
通讯作者：
García-García, A