The evolution of the GALactose utilization pathway in budding yeasts.

The evolution of the GALactose utilization pathway in budding yeasts.
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DOI:
10.1016/j.tig.2021.08.013
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发表时间:
2022-01
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
Rokas A
Rokas A
中科院分区:
其他
文献类型:
--
作者:
Harrison MC;LaBella AL;Hittinger CT;Rokas A

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芽殖酵母的Leloir半乳糖利用或GAL途径,包括面包酵母酿酒酵母(Saccharomyces cerevisiae)和机会人类病原体白色念珠菌(Candida albicans)的Leloir半乳糖利用或GAL途径,分解糖半乳糖用于能量和生物质生产。GAL通路长期以来一直是理解真核生物代谢途径(包括其调节模式)如何进化的模型系统。最近,在不同的芽殖酵母基因组中的结构基因GAL1、GAL7和GAL10的物理连锁已被用作理解基因聚类进化的模型。在这篇综述中,我们总结了令人兴奋的三个不同方面的这一标志性的途径的演变:基因簇组织,GAL基因调控,GAL途径的群体遗传学的最新工作。
The Leloir galactose utilization or GAL pathway of budding yeasts, including that of the baker’s yeast Saccharomyces cerevisiae and the opportunistic human pathogen Candida albicans, breaks down the sugar galactose for energy and biomass production. The GAL pathway has long served as a model system for understanding how eukaryotic metabolic pathways, including their modes of regulation, evolve. More recently, the physical linkage of the structural genes GAL1, GAL7, and GAL10 in diverse budding yeast genomes has been used as a model for understanding the evolution of gene clustering. In this review, we summarize exciting recent work on three different aspects of this iconic pathway’s evolution: gene cluster organization, GAL gene regulation, and the population genetics of the GAL pathway.
DOI: 10.1186/gb-2004-5-6-226
发表时间: 2004
期刊: Genome biology
影响因子: 12.3
作者:
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