Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins.
Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins.
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痘病毒E3泛素连接酶和接头蛋白的研究进展
DOI：
10.3389/fimmu.2021.740223
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Cui H;Zhang Y;Zhang L
痘病毒已经进化出多种先天免疫逃避机制，其中一些涉及痘病毒编码的E3泛素连接酶和衔接蛋白。根据其功能结构域和泛素转移机制，这些痘病毒编码的E3泛素连接酶和接头蛋白可分为五类：PRANC，ANK/BC，BBK，P28/RING和MARCH蛋白。虽然许多痘病毒E3泛素连接酶的底物仍有待发现，但大多数已鉴定的底物是先天免疫系统的组分。本文就痘病毒编码的E3泛素连接酶和衔接蛋白的研究进展进行综述，以期为痘病毒与宿主的相互作用机制提供理论依据。
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins. Based on their functional domains and ubiquitin transfer mechanisms, these poxvirus-encoded E3 ubiquitin ligases and adaptor proteins can be divided into five categories: PRANC, ANK/BC, BBK, P28/RING, and MARCH proteins. Although the substrates of many poxvirus E3 ubiquitin ligases remain to be discovered, most of the identified substrates are components of the innate immune system. In this review, we discuss the current research progress on poxvirus-encoded E3 ubiquitin ligases and adaptor proteins to provide mechanistic insights into the interplay between these viruses and their hosts.
M148R和M149R是欧洲兔子病毒发病机理的两个毒力因子。
影响因子：
4.4
作者：
Blanié S;Mortier J;Delverdier M;Bertagnoli S;Camus-Bouclainville C
通讯作者：
Camus-Bouclainville C