Sequential neurohumoral measurements in patients with congestive heart failure.
Sequential neurohumoral measurements in patients with congestive heart failure.
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充血性心力衰竭患者的连续神经体液测量。
DOI：
10.1016/0002-8703(88)90729-6
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发表时间：
1988
影响因子：
4.8
通讯作者：
Cohn,JN
中科院分区：
文献类型：
--
作者：
Francis,GS;Rector,TS;Cohn,JN
已知患有慢性充血性心力衰竭的患者血浆去甲肾上腺素和血浆肾素活性增加。为了评估神经体液随时间的变化，我们测量了 49 名慢性稳定充血性心力衰竭患者的基线和随访期间的血浆去甲肾上腺素和血浆肾素活性。所有患者均接受洋地黄和利尿剂治疗。 22 名患者接受转化酶抑制剂治疗作为辅助治疗，10 名患者服用肼屈嗪和/或硝酸异山梨酯，7 名患者服用哌唑嗪，10 名患者未进行辅助治疗。患者被分为服用转化酶抑制剂的患者（I 组，n = 22）和未服用转化酶抑制剂的患者（II 组，n = 27）。第一组的随访中位时间（第 25 至 75 个百分位）为 24.3（18 至 27.9）个月，而第二组的随访时间为 18.7（11.9 至 36.5）个月。结果表明，I 组患者的血浆去甲肾上腺素呈显着上升趋势，每月增加 11.7 pg/ml（每月 7.8 至 15 pg/ml，95% 置信区间）。随着时间的推移，第二组患者的血浆去甲肾上腺素也呈现出显着的正向趋势，为每月 6.6 pg/ml（每月 2.2 至 11.1 pg/ml）。此外，II 组血浆肾素活性随着时间的推移呈逐渐上升趋势（中位值每月 0.34 ng/ml/hr；范围 0.13 至 0.54）。数据表明，随着时间的推移，患有慢性、临床稳定的充血性心力衰竭的患者存在神经体液激活的显着趋势。慢性转化酶抑制剂治疗似乎并不能阻止血浆去甲肾上腺素的增加，尽管这些数据不能排除与对照组相比斜率降低的可能性。
Patients with chronic congestive heart failure are known to have increased plasma norepinephrine and plasma renin activity. In order to evaluate neurohumoral changes over time, we measured plasma norepinephrine and plasma renin activity at baseline and sequentially during follow-up in 49 patients with chronic, stable congestive heart failure. All patients were treated with digitalis and diuretics. Converting enzyme inhibitor therapy was prescribed as adjunctive therapy in 22 patients, while 10 patients were taking hydralazine and/or isosorbide dinitrate, seven were taking prazosin, and 10 had no adjunctive therapy. Patients were divided into those taking converting enzyme inhibitors (group I, n = 22) and those not taking converting enzyme inhibitors (group II, n = 27). Group I was followed for a median (25th to 75th percentiles) of 24.3 (18 to 27.9) months, while group II was followed for 18.7 (11.9 to 36.5) months. Results indicate that patients in group I demonstrate a significant positive trend for rise in plasma norepinephrine of 11.7 pg/ml per month (7.8 to 15 pg/ml per month, 95% confidence interval). Patients in group II also demonstrated a significant positive trend in plasma norepinephrine over time of 6.6 pg/ml per month (2.2 to 11.1 pg/ml per month). Moreover, there was a progressive trend upward in plasma renin activity over time in group II (median 0.34 ng/ml/hr per month; range 0.13 to 0.54). The data indicate that there is a significant trend of neurohumoral activation over time in patients with chronic, clinically stable congestive heart failure. The increase in plasma norepinephrine does not appear to be prevented by chronic converting enzyme inhibitor therapy, although these data cannot rule out the possibility of a reduced slope compared to a control group.
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长期卡托普利治疗严重慢性心力衰竭期间的血流动力学反应模式。
影响因子：
37.8
作者：
M. Packer;N. Medina;M. Yushak;J. Meller
通讯作者：
J. Meller
慢性充血性心力衰竭和无衰竭心绞痛心肌儿茶酚胺平衡的比较。
DOI：
10.1016/s0002-9149(84)80208-8
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
Karl Swedberg;C. Viquerat;Jean;M. F. Roizen;Beverley Atherton;W. W. Parmley;Kanu Chatterjee
通讯作者：
Kanu Chatterjee
卡托普利对低肾素充血性心力衰竭的疗效：持续反应性高肾素血症在区分反应者和无反应者中的重要性。
DOI：
10.1016/s0002-9149(84)80206-4
发表时间：
1984
期刊：
The American journal of cardiology
影响因子：
--
作者：
M. Packer;N. Medina;M. Yushak
通讯作者：
M. Yushak
原位心脏移植对充血性心力衰竭交感神经控制机制的影响。
影响因子：
2.8
作者：
T. Levine;M. Olivari;J. N. Cohn
通讯作者：
J. N. Cohn
心力衰竭低剂量卡托普利后血管紧张素 II 水平、血流动力学和交感肾上腺功能。
影响因子：
5.9
作者：
J. Cleland;P. Semple;P. Hodsman;S. Ball;I. Ford;H. Dargie
通讯作者：
H. Dargie