The three adaptation systems of Bacillus subtilis chemotaxis.

The three adaptation systems of Bacillus subtilis chemotaxis.
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DOI:
10.1016/j.tim.2008.07.003
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发表时间:
2008-10
影响因子:
15.9
通讯作者:
Ordal GW
Ordal GW
中科院分区:
生物学1区
文献类型:
--
作者:
Rao CV;Glekas GD;Ordal GW

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适应在细菌趋化性的梯度感应机制中起着至关重要的作用。大肠杆菌趋化性途径使用涉及可逆受体甲基化的单一适应系统。在枯草芽孢杆菌中,趋化途径似乎使用三个适应系统。一种是可逆的受体甲基化,尽管与E.杆菌另外两个涉及CheC、CheD和CheV,它们是在E.杆菌值得注意的是,没有一个系统是绝对需要的适应或能够独立地产生适应。在这篇综述中,我们讨论了这三个新的适应系统在B。subtilis,并提出了一个模型,他们的整合。
Adaptation has a crucial role in the gradient-sensing mechanism that underlies bacterial chemotaxis. The Escherichia coli chemotaxis pathway uses a single adaptation system involving reversible receptor methylation. In Bacillus subtilis, the chemotaxis pathway seems to use three adaptation systems. One involves reversible receptor methylation, although quite differently than in E. coli. The other two involve CheC, CheD and CheV, which are chemotaxis proteins not found in E. coli. Remarkably, no one system is absolutely required for adaptation or is independently capable of generating adaptation. In this review, we discuss these three novel adaptation systems in B. subtilis and propose a model for their integration.
DOI: 10.1038/16483
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