Effects of bone matrix proteins on fracture and fragility in osteoporosis.
Effects of bone matrix proteins on fracture and fragility in osteoporosis.
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DOI：
10.1007/s11914-012-0103-6
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发表时间：
2012-06
影响因子：
4.3
通讯作者：
Vashishth, Deepak
中科院分区：
文献类型：
--
作者：
Sroga, Grazyna E.;Vashishth, Deepak
关键词：
骨密度本身并不能可靠地预测人类和实验动物的骨折风险。因此，其他因素，包括有机骨基质成分的质量及其相互作用，对于理解脆性骨折可能是至关重要的。越来越多的研究表明，除胶原蛋白外，某些非胶原蛋白(NCPs)在骨的结构组织和力学性能中起着重要作用。然而，它们对骨骼强度的贡献在很大程度上仍然不确定。胶原蛋白和NCPs经历不同的翻译后修饰，从而改变细胞外基质的质量和骨对机械负荷的反应。这篇综述的主要焦点是NCPs，它与胶原蛋白一起对骨的结构和力学性能做出贡献。一些NCP通过几种机制影响骨的抗折性，包括非酶糖基化的作用，目前的信息也被介绍。
Bone mineral density alone cannot reliably predict fracture risk in humans and laboratory animals. Therefore, other factors including the quality of organic bone matrix components and their interactions may be of crucial importance to understanding of fragility fractures. Emerging research evidence shows, that in addition to collagen, certain noncollagenous proteins (NCPs) play a significant role in the structural organization of bone and influence its mechanical properties. However, their contribution to bone strength still remains largely undefined. Collagen and NCPs undergo different post-translational modifications, which alter the quality of the extracellular matrix and the response of bone to mechanical load. The primary focus of this overview is on NCPs that, together with collagen, contribute to structural and mechanical properties of bone. Current information on several mechanisms through which some NCPs influence bone’s resistance to fracture, including the role of nonenzymatic glycation, is also presented.
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影响因子：
3.6
作者：
Durbeej, Madeleine
通讯作者：
Durbeej, Madeleine
影响因子：
11.4
作者：
Gilmour, DT;Lyon, GJ;Colledge, WH
通讯作者：
Colledge, WH
DOI：
10.1359/jbmr.080517
发表时间：
2008-10
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Arlot ME;Burt-Pichat B;Roux JP;Vashishth D;Bouxsein ML;Delmas PD
通讯作者：
Delmas PD
影响因子：
2.4
作者：
CALER, WE;CARTER, DR
通讯作者：
CARTER, DR
影响因子：
4.1
作者：
Diab, Tamim;Vashishth, Deepak
通讯作者：
Vashishth, Deepak