Controlling fungal biofilms with functional drug delivery denture biomaterials.
Controlling fungal biofilms with functional drug delivery denture biomaterials.
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DOI：
10.1016/j.colsurfb.2015.12.028
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发表时间：
2016-04-01
期刊：
影响因子：
--
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Wen J;Jiang F;Yeh CK;Sun Y
念珠菌相关假牙口腔炎 (CADS) 是由假牙表面假丝酵母菌定植和生物膜形成引起的，是一个重要的临床问题。我们在此表明，用官能团对传统义齿材料进行改性可以显着提高药物结合能力并控制所得义齿材料的药物释放速率，从而潜在地控制 CADS。在我们的方法中，通过等离子体引发的接枝聚合，在聚甲基丙烯酸甲酯（PMMA）基义齿树脂上接枝了三种聚合物：聚（1-乙烯基-2-吡咯烷酮）（PNVP）、聚（甲基丙烯酸）（PMAA）和聚（甲基丙烯酸2-羟乙酯）（PHEMA）。这三类新型功能化义齿材料的接枝率低至 2 wt%，与原始 PMMA 义齿树脂对照相比，对广泛使用的抗真菌药物咪康唑表现出显着更高的药物结合能力，从而实现持续的药物释放和对念珠菌的有效生物膜控制作用。在三类功能化义齿材料中，PNVP 接枝树脂具有最高的咪康唑结合能力以及最强大的抗真菌和生物膜控制活性。研究了药物结合机制。这些结果证明了药物分子和生物材料上的功能基团之间的特定相互作用的重要性，为 CADS 管理义齿材料和其他用于受控药物输送的相关设备的未来设计提供了线索。具有官能团的义齿树脂表现出显着更高的咪康唑结合能力，并提供有效的念珠菌生物膜控制作用。
Candida -associated denture stomatitis (CADS), caused by colonization and biofilm-formation of Candida species on denture surfaces, is a significant clinical concern. We show here that modification of conventional denture materials with functional groups can significantly increase drug binding capacity and control drug release rate of the resulting denture materials for potentially managing CADS. In our approach, poly(methyl methacrylate) (PMMA)-based denture resins were surface grafted with three kinds of polymers, poly(1-vinyl-2-pyrrolidinone) (PNVP), poly(methacrylic acid) (PMAA), and poly(2-hydroxyethyl methacrylate) (PHEMA), through plasma-initiated grafting polymerization. With a grafting yield as low as 2 wt%, the three classes of new functionalized denture materials showed significantly higher drug binding capacities toward miconazole, a widely used antifungal drug, than the original PMMA denture resin control, leading to sustained drug release and potent biofilm-controlling effects against Candida. Among the three classes of functionalized denture materials, PNVP-grafted resin provided the highest miconazole binding capability and the most powerful antifungal and biofilm-controlling activities. Drug binding mechanisms were studied. These results demonstrated the importance of specific interactions between drug molecules and functional groups on biomaterials, shedding lights on future design of CADS-managing denture materials and other related devices for controlled drug delivery. Denture resins with functional groups showed significantly higher miconazole binding capacities, and provided potent Candida biofilm controlling effects.
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影响因子：
5
作者：
Lin, DM;Kalachandra, S;Offenbacher, S
通讯作者：
Offenbacher, S
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4.6
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作者：
Devine, DM;Higginbotham, CL
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