Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.
Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.
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DOI：
10.1016/j.ijpharm.2014.01.009
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发表时间：
2014-04-10
影响因子：
5.8
通讯作者：
Torchilin, Vladimir P.
中科院分区：
文献类型：
--
作者：
Abouzeid, Abraham H.;Patel, Niravkumar R.;Torchilin, Vladimir P.
关键词：
以人卵巢癌细胞株SK-OV-3及其多药耐药株SK-OV-3-紫杉醇耐药（TR）细胞为研究对象，研究了聚乙二醇-聚乙烯（PEG-PE）、维生素E（VE）、姜黄素和紫杉醇混合胶束对SK-OV-3人卵巢癌细胞株沿着的治疗作用。不同浓度姜黄素的加入并未显著增强紫杉醇对SK-OV-3的体外细胞毒性。然而，在体外观察到联合治疗对SK-0 V-3 TR的明显协同作用。在体内，这种组合治疗对这些细胞系中的每一种产生了三倍的肿瘤抑制。我们的结果表明，这种共负载混合胶束对于治疗耐药卵巢癌可能具有显着的临床优势。
The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
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影响因子：
10.8
作者：
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通讯作者：
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影响因子：
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Torchilin, Vladimir P.
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