Characterization of highly multiplexed monolithic PET / gamma camera detector modules.
Characterization of highly multiplexed monolithic PET / gamma camera detector modules.
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DOI：
10.1088/1361-6560/aab380
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发表时间：
2018-03-29
影响因子：
3.5
通讯作者：
Miyaoka R
中科院分区：
文献类型：
--
作者：
Pierce LA;Pedemonte S;DeWitt D;MacDonald L;Hunter WCJ;Van Leemput K;Miyaoka R
PET探测器使用信号多路复用来减少覆盖给定区域所需的电子通道总数。使用测得的细光束校准数据，我们测试了基于主成分的多路复用方案的闪烁探测器。高度多路复用的检测器信号不再服从标准校准方法。在这项研究中，我们报告的原型复用电路的结果，并提出了一种新的方法来校准检测器模块与复用数据。将50 × 5 × 10 mm 3的LYSO闪烁晶体固定到具有8 × 8个位置输出的位置敏感光电倍增管上，其中一个通道是其他64个通道之和。65通道信号在电阻电路中以65：5或65：7多路复用。以1.52 mm网格图案在晶体表面上扫描511 keV光子的0.9 mm光束，以表征检测器响应。新的方法被开发来拒绝散射事件和执行深度估计来表征探测器响应的校准数据。采用高斯最大似然估计法对测试数据进行了光子相互作用位置估计，并分析了探测器的分辨率和散射抑制能力。我们发现，使用具有1.67 mm深度仓的7通道复用方案（65：7压缩比）具有最佳性能，其中在晶体中心附近具有1.2 mm FWHM（来自0.9 mm光束）的光束轮廓，并且在晶体边缘附近具有1.9 mm FWHM。定位事件遵循预期的Beer-Lambert深度分布。所提出的校准和定位方法表现出散射光子的拒绝率，这是一个55%的改善，超过了总和信号能量加窗方法。
PET detectors use signal multiplexing to reduce the total number of electronics channels needed to cover a given area. Using measured thin-beam calibration data, we tested a principal component based multiplexing scheme for scintillation detectors. The highly-multiplexed detector signal is no longer amenable to standard calibration methodologies. In this study we report results of a prototype multiplexing circuit, and present a new method for calibrating the detector module with multiplexed data. A 50 × 5 × 10 mm3 LYSO scintillation crystal was affixed to a position-sensitive photomultiplier tube with 8 × 8 position-outputs and one channel that is the sum of the other 64. The 65-channel signal was multiplexed in a resistive circuit, with 65:5 or 65:7 multiplexing. A 0.9 mm beam of 511 keV photons was scanned across the face of the crystal in a 1.52 mm grid pattern in order to characterize the detector response. New methods are developed to reject scattered events and perform depth-estimation to characterize the detector response of the calibration data. Photon interaction position estimation of the testing data was performed using a Gaussian Maximum Likelihood estimator and the resolution and scatter-rejection capabilities of the detector were analyzed. We found that using a 7-channel multiplexing scheme (65:7 compression ratio) with 1.67 mm depth bins had the best performance with a beam-contour of 1.2 mm FWHM (from the 0.9 mm beam) near the center of the crystal and 1.9 mm FWHM near the edge of the crystal. The positioned events followed the expected Beer-Lambert depth distribution. The proposed calibration and positioning method exhibited a scattered photon rejection rate that was a 55% improvement over the summed signal energy-windowing method.
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影响因子：
3.5
作者：
Ling, T.;Lewellen, T. K.;Miyaoka, R. S.
通讯作者：
Miyaoka, R. S.
影响因子：
1.8
作者：
Ling, Tao;Lee, Kisung;Miyaoka, Robert S.
通讯作者：
Miyaoka, Robert S.
DOI：
10.1016/j.nima.2016.09.029
发表时间：
2016-12-01
影响因子：
1.4
作者：
Jorge, L. S.;Bonifacio, D. A. B.;Miyaoka, R. S.
通讯作者：
Miyaoka, R. S.
影响因子：
3.5
作者：
Marcinkowski, Radoslaw;Mollet, Pieter;Vandenberghe, Stefaan
通讯作者：
Vandenberghe, Stefaan
影响因子：
3.5
作者：
Borghi, Giacomo;Tabacchini, Valerio;Schaart, Dennis R.
通讯作者：
Schaart, Dennis R.