Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population.
Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population.
复制标题
农村成年人口支气管高反应性和哮喘的患病率。
作者：
A. Woolcock;J. Peat;C. Salome;K. Yan;S. Anderson;R. Schoeffel;G. McCowage;T. Killalea
支气管高反应性在成人人群中的患病率尚不清楚。记录其患病率和分布，并确定与之相关的因素，随机抽样的成年人口的布塞尔顿，西澳大利亚州进行了研究。测定肺功能、支气管对组胺的反应性和皮肤点刺试验的特应性反应。通过问卷调查确定呼吸道症状。从916名受试者中获得数据。其中，876人接受了组胺吸入试验，10.5%的人发现了对组胺的支气管高反应性（定义为组胺剂量引起FEV1下降20%，等于或小于3.9 μ mol）。另外40例肺功能较差的受试者接受了支气管扩张剂测试，发现12例有支气管高反应性（定义为FEV1增加超过15%），使支气管高反应性的总患病率为11.4%。当前哮喘的患病率（定义为支气管高反应性加上过去12个月内与哮喘一致的症状）为5.9%。支气管高反应性在研究人群中的分布是连续的。它与呼吸道症状、特应性、吸烟和肺功能异常之间存在显著相关性（所有相关性p均小于0.001）。与年龄、性别或近期呼吸道感染无关。
The prevalence of bronchial hyperresponsiveness in adult populations is not known. To document its prevalence and distribution and to determine the factors associated with it, a random sample of the adult population of Busselton, Western Australia, was studied. Spirometric function, bronchial responsiveness to histamine, and atopic responses to skin prick tests were measured. Respiratory symptoms were determined by questionnaire. Data were obtained from 916 subjects. Of these, 876 underwent a histamine inhalation test and bronchial hyperresponsiveness to histamine (defined as a dose of histamine provoking a 20% fall in FEV1 equal to or less than 3.9 mumol) was found in 10.5%. Another 40 subjects with poor lung function were tested with a bronchodilator and 12 were found to have bronchial hyperresponsiveness (defined as a greater than 15% increase in FEV1), making the total prevalence of bronchial hyperresponsiveness 11.4%. The prevalence of current asthma, defined as bronchial hyperresponsiveness plus symptoms consistent with asthma in the last 12 months, was 5.9%. The distribution of bronchial hyperresponsiveness in the studied population was continuous. There was a significant association between it and respiratory symptoms, atopy, smoking, and abnormal lung function (p less than 0.001 for all associations). There was no association with age, sex, or recent respiratory tract infection.
成人气道对冷空气、吸烟和过敏性反应与呼吸道症状和肺功能的关系。
DOI：
10.1164/arrd.1984.130.2.198
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Welty,C;Weiss,ST;Tager,IB;Munoz,A;Becker,C;Speizer,FE;IngramJr,RH
通讯作者：
IngramJr,RH