Bone measurement by enhanced contrast image analysis: ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis.
Bone measurement by enhanced contrast image analysis: ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis.
复制标题
通过增强对比图像分析进行骨测量:切除卵巢和完整的食蟹猴作为人类绝经后骨质疏松症的模型。
DOI:
10.1002/ajpa.1330670204
复制
发表时间:
1985
影响因子:
2.8
通讯作者:
Miller,LC
中科院分区:
文献类型:
--
作者:
Bowles,EA;Weaver,DS;Telewski,FW;Wakefield,AH;Jaffe,MJ;Miller,LC
This paper presents an image enhancement and analysis system (DARWIN) based on an inexpensive microcomputer and applies the system to two bone morphometry problems relevant to postmenopausal osteoporosis. Using ovariectomized and intact femaleMacaca fascicularisas a model, we examined the radiodensity of the sixth lumbar vertebra and the cross‐section area of the right femur. Significantly lower bone density was observed in the vertebral segments of the ovariectomized animals. No significant differences were observed in comparisons of the femoral cross sections. The reduction in radiographic density of the ovariectomized animals' vertebrae is similar to that observed in postmenopausal women, supporting the use of female cynomolgus macaques as models of bone loss in postmenopausal osteoporosis.
影响因子:
7.4
作者:
F. Telewski;Andrew H. Wakefield;Mordecai J. Jaffe
通讯作者:
Mordecai J. Jaffe
DOI:
10.1210/jcem-42-3-537
发表时间:
1976
期刊:
The Journal of clinical endocrinology and metabolism
影响因子:
--
作者:
S. Teitelbaum;E. Rosenberg;C. Richardson;L. Avioli
通讯作者:
L. Avioli