Pattern visual evoked potentials show an inferior–superior topographic shift through maturation in childhood
Pattern visual evoked potentials show an inferior–superior topographic shift through maturation in childhood
复制标题
图案视觉诱发电位显示出童年时期成熟过程中的劣等-优地形转变
DOI：
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
D. Thompson
中科院分区：
文献类型：
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作者：
O. Marmoy;L. Horvat;M. Cortina;D. Thompson
The pattern‐reversal visual evoked potential (prVEP) is an established routine clinical test. Its objectivity is particularly valuable for assessing visual pathway function in children. International standards specify at a minimum that an active electrode is placed on the occiput at Oz, but we find an additional inferior electrode at the inion (Iz) provides larger and more sensitive prVEPs in young persons. This study assesses the significance and age‐dependence of these observations. PrVEPs were recorded from 1487 patients considered ophthalmologically normal aged <20 years old, to a range of check widths including International Society for Clinical Electrophysiology of Vision (ISCEV) standard large (50′) and small (12.5′) check widths. P100 peak‐time and amplitude from both electrode sites were analysed. A subset of 256 children were studied longitudinally by fitting logistic regression models including a random effect on subjects. PrVEPs were largest over the Iz electrode for the majority of infants and children. This transitioned with age to become equal or smaller at Oz as a function of check width. For ISCEV standard large and small check widths, transition periods were ∼8 and ∼12 years of age, respectively. We estimated abnormal result classifications of 3.7% with use of an Oz electrode alone, which decreases to 0.0–0.5% when adding or using an Iz electrode. The inferior dominance of prVEP topography in children may be explained by age‐related anatomical changes altering the cortical dipole, combined with physiological maturation of the neural generators of the prVEP. We recommend the Iz electrode is used routinely in recording of prVEPs in children.
影响因子：
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作者：
PFEFFERBAUM, A;MATHALON, DH;LIM, KO
通讯作者：
LIM, KO