Recent progress on our understanding of water around biomolecules

Recent progress on our understanding of water around biomolecules
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我们对生物分子周围水的理解的最新进展

DOI:
10.1016/j.molliq.2004.08.011
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发表时间:
2005
影响因子:
6
通讯作者:
Jichen Li
Jichen Li
中科院分区:
化学2区
文献类型:
--
作者:
I. Michalarias;Xiuli Gao;R. Ford;Jichen Li

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本研究的目的是利用非弹性中子散射(INS)技术在分子水平上研究水与不同生物分子的相互作用。这些方法提供了所谓的界面(或结合)的水分子,是在几个水化壳的大分子,并表明,界面水分子可以很容易地区分从那些在散装(散装水),特别是使用数据的非弹性中子散射在20-130毫电子伏范围内对应的librational峰和分子的光学峰。水的分子动力学模拟的进展,加上界面水的中子散射测量,可以更好地了解生物分子(如DNA和蛋白质)周围的水的水合特性。
The aim of this research was to study the interaction of water with different biomolecules on the molecular level using inelastic neutron scattering (INS) techniques. These methods provide information on the so-called interfacial (or bound) water molecules that are within a few hydration shells of the macromolecules and show that the interfacial water molecules can be readily distinguished from those in the bulk (bulk water), especially using data for inelastic neutron scattering over the 20–130 meV range corresponding to the librational peak and the molecular optic peaks. Advances in molecular dynamics simulations of water, coupled with neutron scattering measurements of interfacial water could lead to a better understanding of the hydration properties of water around biomolecules such as DNA and proteins.
Kita, Yasuyuki:“β-内酰胺环的前所未有的裂解:无环 N、O-和 N,S-缩醛的新合成”J. Perkin Trans。
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DOI: 10.1038/171737a0
发表时间: 1953-01-01
期刊: NATURE
影响因子: 64.8
作者:
WATSON, JD;CRICK, FHC
通讯作者: CRICK, FHC