Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study.
Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study.
复制标题
DOI：
10.1136/bmjopen-2012-001915
复制
发表时间：
2013-01-24
期刊：
影响因子：
2.9
通讯作者：
Mueller K
中科院分区：
文献类型：
--
作者：
Raschpichler M;Straatman K;Schroeter ML;Arelin K;Schlögl H;Fritzsch D;Mende M;Pampel A;Böttcher Y;Stumvoll M;Villringer A;Mueller K
研究代谢重要的内脏脂肪组织（VAT）与以体重指数（BMI）测量的体重相比，是否与脑结构和功能变化有不同的关系。此外，我们的目的是调查这些影响是否随年龄而变化。横向调查探索性的大学诊所，综合研究和治疗中心。我们从该市登记处随机邀请的202名志愿者中纳入了100名（平均BMI=26.0 kg/m²，42名女性），分为两个年龄组：10-中年（n=51，20-45岁，平均BMI=24.9，24名女性）和老年（n=49，65-70岁，平均BMI=27.0，18名女性）。 VAT、BMI、皮下腹部脂肪组织、脑结构（灰质密度）、功能性脑结构（特征向量中心性，EC）。我们发现，年轻参与者的小脑结构随着VAT的增加而丧失，最显著的是在参与运动处理的区域。这种负相关在老年人中消失。对大脑功能结构的研究再次显示了VAT与小脑的反向相关性，而现在参与认知和情感处理的区域是重要的。虽然我们检测到类似的结果EC使用BMI，显着的年龄相互作用的大脑结构和功能架构，只有使用增值税。内脏肥胖与小脑结构和功能的变化有关，而所涉及的区域有助于运动，认知和情绪过程。此外，这些关联似乎与年龄有关，年轻人的大脑受到不利影响。
To investigate whether the metabolically important visceral adipose tissue (VAT) relates differently to structural and functional brain changes in comparison with body weight measured as body mass index (BMI). Moreover, we aimed to investigate whether these effects change with age. Cross-sectional, exploratory. University Clinic, Integrative Research and Treatment Centre. We included 100 (mean BMI=26.0 kg/m², 42 women) out of 202 volunteers randomly invited by the city's registration office, subdivided into two age groups: young-to-mid-age (n=51, 20–45 years of age, mean BMI=24.9, 24 women) versus old (n=49, 65–70 years of age, mean BMI=27.0, 18 women). VAT, BMI, subcutaneous abdominal adipose tissue, brain structure (grey matter density), functional brain architecture (eigenvector centrality, EC). We discovered a loss of cerebellar structure with increasing VAT in the younger participants, most significantly in regions involved in motor processing. This negative correlation disappeared in the elderly. Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT. Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. Furthermore, these associations seem to be age dependent, with younger adults’ brains being adversely affected.
登录
查看更多内容
影响因子：
4.4
作者：
Kaza, Evangelia;Klose, Uwe;Lotze, Martin
通讯作者：
Lotze, Martin
影响因子：
3.3
作者：
JEZZARD, P;BALABAN, RS
通讯作者：
BALABAN, RS
DOI：
10.1126/science.1151710
发表时间：
2007-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerken T;Girard CA;Tung YC;Webby CJ;Saudek V;Hewitson KS;Yeo GS;McDonough MA;Cunliffe S;McNeill LA;Galvanovskis J;Rorsman P;Robins P;Prieur X;Coll AP;Ma M;Jovanovic Z;Farooqi IS;Sedgwick B;Barroso I;Lindahl T;Ponting CP;Ashcroft FM;O'Rahilly S;Schofield CJ
通讯作者：
Schofield CJ
影响因子：
56.9
作者：
Bouret, SG;Draper, SJ;Simerly, RB
通讯作者：
Simerly, RB
影响因子：
4.8
作者：
Kurth, Florian;Levitt, Jennifer G.;Narr, Katherine L.
通讯作者：
Narr, Katherine L.