Relationship between autonomic nervous system function and continuous interstitial glucose measurement in patients with type 2 diabetes.
Relationship between autonomic nervous system function and continuous interstitial glucose measurement in patients with type 2 diabetes.
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DOI：
10.1155/2014/835392
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发表时间：
2014
影响因子：
4.3
通讯作者：
Makrilakis K
中科院分区：
文献类型：
--
作者：
Kalopita S;Liatis S;Thomakos P;Vlahodimitris I;Stathi C;Katsilambros N;Tentolouris N;Makrilakis K
目标。本研究的目的是检查 2 型糖尿病 (T2D) 患者的自主神经系统功能与血糖变异性 (GV) 之间是否存在关系。方法。总共 50 名（29 名男性）2 型糖尿病患者（平均年龄 58.4 ± 9.9 岁，中位糖尿病病程 5.5 [IQR 2.0–9.25] 年）服用口服降糖药，同时连续 24 小时进行心电图记录和皮下血糖监测。结果。调整 HbA1c 和糖尿病持续时间后，心率变异性总功率 (HRV) 与平均间质组织葡萄糖 (MITG) 的标准差以及整个记录期间（r：-0.29，P = 0.052；r：-0.30，P = 0.047）和夜间（r：-0.29，P = 0.047；r：r： −0.31，P = 0.03，分别）。大多数 HRV 时域指标与 MITG 和 M 值的标准差显着相关。夜间 HRV 记录的这些相关性更强。 HRV 参数与 MAGE 之间未发现显着关联。结论。 T2D 患者的 HRV 与 GV 呈负相关，这可能是 GV 与自主神经功能障碍之间因果关系的标志。需要前瞻性研究来进一步研究 GV 在糖尿病长期并发症发病机制中的重要性。
Aims. The Aim of the present study was to examine whether there is a relationship between autonomic nervous system function and glycemic variability (GV) in patients with type 2 diabetes (T2D). Methods. A total of 50 (29 males) patients with T2D (mean age 58.4 ± 9.9 years, median diabetes duration 5.5 [IQR 2.0–9.25] years), on oral antidiabetic agents, underwent ECG recording and subcutaneous glucose monitoring, simultaneously and continuously, for 24 hours. Results. After adjustment for HbA1c and diabetes duration, total power of heart rate variability (HRV) was inversely associated with the standard deviation of the mean interstitial tissue glucose (MITG) and with the M-value during the entire recording (r: −0.29, P = 0.052; r: −0.30, P = 0.047, resp.) and during the night (r: −0.29, P = 0.047; r: −0.31, P = 0.03, resp.). Most of the HRV time-domain indices were significantly correlated with standard deviation of the MITG and the M-value. These correlations were stronger for the HRV recordings during the night. No significant association was found between HRV parameters and MAGE. Conclusions. HRV is inversely associated with GV in patients with T2D, which might be a sign of causation between GV and autonomic dysfunction. Prospective studies are needed to further investigate the importance of GV in the pathogenesis of long-term complications of diabetes.
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