Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica.
Recent Advances in Producing Sugar Alcohols and Functional Sugars by Engineering Yarrowia lipolytica.
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DOI：
10.3389/fbioe.2021.648382
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发表时间：
2021
影响因子：
5.7
通讯作者：
Lv Y
中科院分区：
文献类型：
--
作者：
Abbasi AR;Liu J;Wang Z;Zhao A;Ying H;Qu L;Alam MA;Xiong W;Xu J;Lv Y
糖醇和功能糖在食品、医药、化工等领域有着广泛的应用。然而，天然存在的糖醇和功能糖的量较少限制了它们的应用。酶和全细胞催化剂生产正在成为主要的替代品。解脂耶氏酵母的特性使其成为一种很有前途的糖醇和功能糖生产菌。然而，仍有一些问题有待解决。鉴于国内外对Y.本文不仅介绍了利用重组酵母菌生产糖醇（木糖醇、D-苏糖醇和木糖醇）和功能糖（异麦芽酮糖、海藻糖、低聚果糖和低聚半乳糖）的最新研究进展，还介绍了利用重组酵母菌生产功能糖的最新研究进展。除此之外，还致力于基因发现、途径工程、扩大底物范围、生物过程工程和新的育种方法的研究，以解决上述问题。
The sugar alcohols and functional sugars have wide applications in food, pharmaceutical, and chemical industries. However, the smaller quantities of natural occurring sugar alcohols and functional sugars restricted their applications. The enzymatic and whole-cell catalyst production is emerging as the predominant alternatives. The properties of Yarrowia lipolytica make it a promising sugar alcohol and functional sugar producer. However, there are still some issues to be resolved. As there exist reviews about the chemical structures, physicochemical properties, biological functions, applications, and biosynthesis of sugar alcohols and/or functional sugars in Y. lipolytica, this mini review will not only update the recent advances in enzymatic and microbial production of sugar alcohols (erythritol, D-threitol, and xylitol) and functional sugars (isomaltulose, trehalose, fructo-oligosaccharides, and galacto-oligosaccharides) by using recombinant Y. lipolytica but also focus on the studies of gene discovery, pathway engineering, expanding substrate scope, bioprocess engineering, and novel breeding methods to resolve the aforementioned issues.
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