T(1ρ) MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe.
T(1ρ) MRI in Alzheimer's disease: detection of pathological changes in medial temporal lobe.
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DOI：
10.1111/j.1552-6569.2010.00467.x
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Borthakur A
中科院分区：
文献类型：
--
作者：
Haris M;Singh A;Cai K;McArdle E;Fenty M;Davatzikos C;Trojanowski JQ;Melhem ER;Clark CM;Borthakur A
AD的早期和非侵入性诊断的需要需要发展基于成像的技术。作为替代方案，在阿尔茨海默病（AD）、轻度认知障碍（MCI）和年龄匹配的对照组的大脑中测量磁共振成像（MRI）弛豫时间常数（T1ρ），以确定T1ρ值是否与神经学诊断相关。在1.5Tesla Siemens临床MRI扫描仪上对AD（n = 48）、MCI（n = 45）和年龄匹配的对照组（n = 41）进行MRI。通过拟合每个像素的强度作为自旋锁定脉冲持续时间的函数来生成T1ρ图。计算内侧颞叶（MTL）灰质（GM）和白色质（WM）的T1ρ值。对照组GM和WM T1ρ值分别为87.5 ± 1.2 ms和80.5 ± 1.4 ms，MCI组为90.9 ± 1.3 ms和84.1 ± 1.7 ms，AD组为91.9 ± 1.8 ms和88.3 ± 1.3 ms。与对照组相比，AD患者WM T1ρ增加9%，GM T1ρ增加5%。与对照组相比，MCI个体WM和GM的T1ρ均增加4%。AD组WM的T1ρ较MCI组增加5%。AD患者WM的T1ρ和MTL的GM增高可能与常规MRI不明显的病理改变有关。
The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ ) was measured in brains of Alzheimer’s disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values correlated with the neurological diagnosis. MRI was performed on AD (n = 48), MCI (n = 45), and age-matched control (n = 41), on a 1.5 Tesla Siemens clinical MRI scanner. T1ρ maps were generated by fitting each pixel’s intensity as a function of the duration of the spin-lock pulse. T1ρ values were calculated from the gray matter (GM) and white matter (WM) of medial temporal lobe (MTL). GM and WM T1ρ values were 87.5 ± 1.2 ms and 80.5 ± 1.4 ms, respectively, in controls, 90.9 ± 1.3 ms and 84.1 ± 1.7 ms in MCI, and 91.9 ±.8 ms and 88.3 ± 1.3 ms in AD cohorts. Compared to control, AD patients showed 9% increased WM T1ρ and 5% increased GM T1ρ. Compared to control, MCI individuals showed 4% increased T1ρ both in WM and GM. A 5% increased T1ρ was found in WM of AD over MCI. The increased T1ρ in WM and GM of MTL in AD may be associated with the pathological changes that are not evident on conventional MRI.
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